The validity of the SF-12 and SF-6D instruments in people living with HIV/AIDS in Kenya

Health and Quality of Life Outcomes

Research

Richard T. Lester¹  Mia L. van der Kop²  Anik R. Patel³  Lidia Engel⁴  Larry D. Lynd⁵  Sarah Karanja⁶  Paul Ritvo⁷  Carlo A. Marra⁸ 

[1] Department of Medicine, University of British Columbia, 828 West 10th Avenue, V5Z 1M9, Vancouver, BC, Canada;Department of Medicine, University of British Columbia, 828 West 10th Avenue, V5Z 1M9, Vancouver, BC, Canada;Department of Public Health Sciences/Global Health (IHCAR), Karolinska Institutet, Widerströmska Huset, Tomtebodavägen 18A, 171-77, Stockholm, Sweden;Department of Medicine, University of British Columbia, 828 West 10th Avenue, V5Z 1M9, Vancouver, BC, Canada;Faculty of Pharmaceutical Science, University of British Columbia, 2405 Westbrook Mall, Vancouver, Canada;Faculty of Health Sciences, Simon Fraser University, 8888 University Drive, V5A 1S6, Burnaby, BC, Canada;Deakin University, Geelong Australia, Faculty of Health, School of Health and Social Development, 221 Burwood Highway, Burwood, 3125, Victoria, Australia;Faculty of Pharmaceutical Science, University of British Columbia, 2405 Westbrook Mall, Vancouver, Canada;Center for Health Evaluation and Outcomes Science, St. Paul’s Hospital, 588 – 1081 Burrard Street, V6Z 1Y6, Vancouver, BC, Canada;Monitoring, Evaluation and Research Unit, Amref Health Africa in Kenya, P.O. Box 30125-00100, Nairobi, Kenya;School of Kinesiology & Health Sciences, York University, 160 Campus Walk, M3J 1P3, North York, ON, Canada;School of Pharmacy, University of Otago, Dunedin, New Zealand;

关键词: Quality of life;    Short-form 12;    Kiswahili;    HIV;    Health state utility;    SF6D;   

DOI  :  10.1186/s12955-017-0708-7

 received in 2016-10-14, accepted in 2017-06-21,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundHealth-related quality of life (HRQoL) and health state utility value (HSUV) measurements are vital components of healthcare clinical and economic evaluations. Accurate measurement of HSUV and HRQoL require validated instruments. The 12-item Short-Form Health Survey (SF-12) is one of few instruments that can evaluate both HRQoL and HSUV, but its validity has not been assessed in people living with HIV/AIDS (PLWHA) in east Africa, where the burden of HIV is high.MethodsThis cross-sectional study used baseline data from a randomized trial involving PLWHA in Kenya. Data included responses from a translated and adapted SF-12 survey as well as key demographic and clinical data. Construct validity of the survey was examined by testing the SF-12’s ability to distinguish between groups known in advance to have differences in their health based on their disease severity. We classified disease severity based on established definitions from the US Center for Disease Control (CDC) and WHO, as well as a previously studied viral load threshold. T-tests and ANOVA were used to test for differences in HRQoL and HSUV scores. Area under the receive operator curve (AUC) was used to test the discriminative ability of the HRQoL and HSUV instruments.ResultsDifferences in physical component scores met the minimum clinically important difference among participants with more advanced HIV when defined by CD4 count (4.3 units) and WHO criteria (compared to stage 1, stages 2, 3 and 4 were 2.0, 7.2 and 9.8 units lower respectively). Mental score differences met the minimum clinically important difference between WHO stage 1 and stage 4 patients (4.4). Differences in the HSUV were statistically lower in more advanced HIV by all three definitions of severity. The AUC showed poor to weak discriminatory ability in most analyses, but had fair discriminatory ability between WHO clinical stage 1 and clinical stage 4 individuals (AUC = 0.71).ConclusionOur findings suggest that the Kiswahili translated and adapted version of the SF-12 could be used as an assessment tool for physical health, mental health and HSUV for Kiswahili-speaking PLHWA.Trial registrationClinical trials.gov identifier: NCT00830622. Registered 26 January 2009.

【 授权许可】

CC BY   
© The Author(s). 2017