The prognostic value of MGMT promoter status by pyrosequencing assay for glioblastoma patients’ survival: a meta-analysis

World Journal of Surgical Oncology

Review

Shuying Wang¹  Yunhong Zha¹  Chengwei Song¹  Li Li²  Hailong Zhao³ 

[1] Department of Neurology, The First Hospital of Yichang, Institute of Translational Neuroscience, Three Gorges University College of Medicine, Yichang, People’s Republic of China;Wuhan Institute of Biological Products Co., Ltd., Wuhan, People’s Republic of China;null;

关键词: MGMT;    Meta-analysis;    Glioblastoma;    Hazard ratio;    Pyrosequencing;    Survival;    Prognostic biomarker;   

DOI  :  10.1186/s12957-016-1012-4

 received in 2016-06-19, accepted in 2016-09-28,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe prognostic value of the status of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation measured by pyrosequencing assay (PSQ) among glioblastoma (GBM) patients was examined in meta-analysis.MethodsEligible studies that reported the association between the status of MGMT promoter methylation by PSQ and prognostic value of GBM patients from three electronic databases, like PubMed, EMBASE, and Cochrane library were involved in meta-analysis. Using Stata 11.0, the summarized hazard ratios (HRs) for overall survival (OS) and the progression-free survival (PFS) with 95 % confidence interval (CI) were calculated.ResultsEleven studies were included to evaluate the relationship between the status of MGMT promoter methylation and GBM patients’ survival. Overall, regardless of the cut-off value of methylation status of MGMT promoter by PSQ, methylated-positive patients were evidently associated with an improved HRs for OS (HRs = 0.50, 95 % CI = 0.35–0.66). For summary, progression-free survival (PFS) from four studies, the prognostic effect was also found (HRs = 0.56, 95 % CI = 0.32–0.80).ConclusionMethylation positivity of MGMT promoter by PSQ was related to an increased survival in GBM patients. Thus, the status of MGMT promoter methylation by PSQ might be used to be a prognostic biomarker, and GBM patients might have a vested interest in clinical application of standardized PSQ.

【 授权许可】

CC BY   
© The Author(s). 2016