Prostate-specific antigen density values among patients with symptomatic prostatic enlargement in Nigeria

World Journal of Surgical Oncology

Research

Adesina S. O. Aderibigbe¹  Samuel R. Ohayi²  Kevin N. Echetabu³  Fred O. Ugwumba⁴  Ikenna I. Nnabugwu⁴  Francis O. Ozoemena⁴  Emeka I. Udeh⁵ 

[1] Department of Pathology, ESUT University Teaching Hospital, Park Lane, Enugu, Nigeria;Department of Radiology, University of Nigeria Teaching Hospital, Enugu, Nigeria;Department of Surgery, University of Nigeria Teaching Hospital, Enugu, Nigeria;Department of Surgery, University of Nigeria, Enugu, Nigeria;Department of Surgery, University of Nigeria, Enugu, Nigeria;Department of Surgery, Faculty of medicine, College of medicine, University of Nigeria, Enugu, Nigeria;

关键词: Prostate-specific antigen density;    Nigerian men;    Symptomatic prostatic enlargement;   

DOI  :  10.1186/s12957-016-0921-6

 received in 2015-08-24, accepted in 2016-06-14,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThis study aims to estimate the prostate-specific antigen density (PSAD) cutoff level for detecting prostate cancer (CAP) in Nigerian men with “grey zone PSA” (4–10 ng/ml) and normal digital rectal examination findings. We addressed this research question: Is the international PSAD cutoff of 0.15 ideal for detecting CAP in our symptomatic patients with “grey zone PSA?”MethodsAim: To estimate the prostate-specific antigen density (PSAD) cutoff level for detecting CAP in Nigerian men with “grey zone PSA” (4–10 ng/ml) and normal digital rectal examination findings.Design: Prospective.Setting: A tertiary medical center in Enugu, Nigeria.Participants: Two hundred and fifty-four men with either benign prostatic hyperplasia (BPH) or CAP were recruited.Intervention: Patients with PSA above 4 ng/ml or abnormal digital rectal examination or hypoechoic lesion in the prostate were biopsied.Outcome measures: PSAD and histology report of BPH or CAP.ResultsNinety-seven patients had CAP while 157 had benign prostatic hyperplasia (BPH). Seventy-two patients had their serum PSA value within the range of 4.0 and 10 ng/ml. PSAD cutoff level to detect CAP was 0.04 (sensitivity 95.88 %; specificity 28.7 %).ConclusionsThe PSAD cutoff level generated for Nigerian men in this study is 0.04 which is relatively different from international consensus. This PSAD cutoff level has a positive correlation with histology and could detect patients with CAP who have “grey zone PSA.”

【 授权许可】

CC BY   
© The Author(s). 2016