Mechanotransduction: use the force(s)

BMC Biology

Forum

Nicolas Biais¹  Celeste M. Nelson²  Beth L. Pruitt³  Jens Moeller⁴  Ben Fabry⁵  Walter Federle⁶  Carina Wollnik⁷  Galina Kudryasheva⁷  Florian Rehfeldt⁷  Ewa K. Paluch⁸ 

[1] Biology Department, Brooklyn College and the Graduate Center of the City University of New York, 2900 Bedford avenue, 11210, Brooklyn, NY, USA;Chemical & Biological Engineering, Princeton University, 303 Hoyt Laboratory, William Street, 08544, Princeton, NJ, USA;Department of Mechanical Engineering and Molecular and Cellular Physiology, Microsystems Laboratory, Stanford University, by courtesy, 496 Lomita Mall, Durand Building Rm 213, 94305, Stanford, CA, USA;Department of Mechanical Engineering, Microsystems Laboratory, Stanford University, 496 Lomita Mall, Durand Building Rm 102, 94305, Stanford, CA, USA;Department of Physics, University of Erlangen-Nuremberg, Henkestrasse 91, 91052, Erlangen, Germany;Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ, Cambridge, UK;Georg-August-University, 3rd Institute of Physics – Biophysics, Friedrich-Hund-Platz 1, 37077, Göttingen, Germany;MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, WC1E 6BT, London, UK;

关键词: Focal Adhesion;    Physical Force;    Adhesive Contact;    Adhesive Stress;    Traction Force Microscopy;   

DOI  :  10.1186/s12915-015-0150-4

来源: Springer

【 摘 要 】

Mechanotransduction - how cells sense physical forces and translate them into biochemical and biological responses - is a vibrant and rapidly-progressing field, and is important for a broad range of biological phenomena. This forum explores the role of mechanotransduction in a variety of cellular activities and highlights intriguing questions that deserve further attention.

【 授权许可】

CC BY   
© Paluch et al. 2015