Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women

Nutrition Journal

Research

Surabhi Bhutani¹  Monica C Klempel¹  John F Trepanowski¹  Cynthia M Kroeger¹  Krista A Varady¹ 

[1] Department of Kinesiology and Nutrition, University of Illinois at Chicago, 1919 West Taylor Street, Room 506F, 60612, Chicago, IL, USA;

关键词: Intermittent fasting;    Calorie restriction;    Liquid diet;    Body weight;    Visceral fat;    Cholesterol;    Coronary heart disease;    Obese women;   

DOI  :  10.1186/1475-2891-11-98

 received in 2012-08-14, accepted in 2012-11-20,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundIntermittent fasting (IF; severe restriction 1 d/week) facilitates weight loss and improves coronary heart disease (CHD) risk indicators. The degree to which weight loss can be enhanced if IF is combined with calorie restriction (CR) and liquid meals, remains unknown.ObjectiveThis study examined the effects of IF plus CR (with or without a liquid diet) on body weight, body composition, and CHD risk.MethodsObese women (n = 54) were randomized to either the IFCR-liquid (IFCR-L) or IFCR-food based (IFCR-F) diet. The trial had two phases: 1) 2-week weight maintenance period, and 2) 8-week weight loss period.ResultsBody weight decreased more (P = 0.04) in the IFCR-L group (3.9 ± 1.4 kg) versus the IFCR-F group (2.5 ± 0.6 kg). Fat mass decreased similarly (P < 0.0001) in the IFCR-L and IFCR-F groups (2.8 ± 1.2 kg and 1.9 ± 0.7 kg, respectively). Visceral fat was reduced (P < 0.001) by IFCR-L (0.7 ± 0.5 kg) and IFCR-F (0.3 ± 0.5 kg) diets. Reductions in total and LDL cholesterol levels were greater (P = 0.04) in the IFCR-L (19 ± 10%; 20 ± 9%, respectively) versus the IFCR-F group (8 ± 3%; 7 ± 4%, respectively). LDL peak particle size increased (P < 0.01), while heart rate, glucose, insulin, and homocysteine decreased (P < 0.05), in the IFCR-L group only.ConclusionThese findings suggest that IF combined with CR and liquid meals is an effective strategy to help obese women lose weight and lower CHD risk.

【 授权许可】

Unknown   
© Klempel et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.