Malaria research challenges in low prevalence settings

Malaria Journal

Commentary

William J Moss¹  Tamaki Kobayashi¹  Gillian Stresman²  Clive Shiff³  Aniset Kamanga⁴  Philip E Thuma⁵  Sungano Mharakurwa⁶ 

[1] Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 21205, Baltimore, MD, USA;Department of Immunology and Infection, London School of Hygiene & Tropical Medicine, W1CE 7HT, London, UK;Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 21205, Baltimore, MD, USA;Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, W1CE 7HT, London, UK;Malaria Institute at Macha, Choma, Zambia;Malaria Institute at Macha, Choma, Zambia;Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 21205, Baltimore, MD, USA;

关键词: Malaria;    Malaria Transmission;    Rapid Diagnostic Test;    Mass Drug Administration;    Malaria Elimination;   

DOI  :  10.1186/1475-2875-11-353

 received in 2012-09-06, accepted in 2012-10-18,  发布年份 2012

来源: Springer

【 摘 要 】

The prevalence of malaria has reduced significantly in some areas over the past decade. These reductions have made local elimination possible and the research agenda has shifted to this new priority. However, there are critical issues that arise when studying malaria in low transmission settings, particularly identifying asymptomatic infections, accurate detection of individuals with microparasitaemic infections, and achieving a sufficient sample size to have an adequately powered study. These challenges could adversely impact the study of malaria elimination if they remain unanswered.

【 授权许可】

Unknown   
© Stresman et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.