Association of liver X receptor α (LXRα) gene polymorphism and coronary heart disease, serum lipids and glucose levels

Lipids in Health and Disease

Research

Jing Zhang¹  Jun-JIE Li²  Hui-Lan Luo²  Jing-Li Miao²  Qiao-Xiang Yin²  Xiao-Yan Zhang²  Zong-Xue Li²  Yuan-Yuan Li²  Yun-Fei Zhou² 

[1] Combination of traditional Chinese and Western Medicine Hospital of Southern Medical University, 510515, Guangzhou, China;The cadre ward of General Hospital of the Air Force PLA, No. 30, Fucheng Road, Haidian District, 100142, Beijing, China;

关键词: Liver X receptor α;    Gene;    Coronary heart disease;    Polymorphism;   

DOI  :  10.1186/1476-511X-13-34

 received in 2013-12-09, accepted in 2014-02-10,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundTo explore the relationship between the liver X receptor α gene (LXRα) rsl2221497 polymorphism and the susceptibility of coronary heart disease (CHD) and serum lipids and glucose levels.MethodsThe single fluorescently labeled probes technique was used to detect the genotype of rsl2221497 in LXRα gene in 240 CHD patients and 250 healthy control subjects. The difference of genotype distribution between the two groups was analyzed using of Chi-square test. The serum lipids and glucose levels between the different genotypes were also compared.ResultsThe risk of CHD in carriers with (AA + GA) genotype was 1.76 times as that in the GG genotype carriers (OR = 1.76, 95% CI: 1.18-2.87, P <0.05), and the risk of CHD in carriers with A allele increased 0.88 times compared to that in G allele carriers (OR = 1.88, 95% CI:1.21-3.43, P <0.01). Logistic regression analysis showed that after adjusting for other confounding factors, A allele was an independent risk for CHD. However, there were no differences in serum lipids and glucose levels between each genotype.ConclusionsThe rsl2221497 polymorphism in LXRα gene was associated with susceptibility of CHD in Han population.

【 授权许可】

Unknown   
© Zhou et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.