Safety and feasibility of countering neurological impairment by intravenous administration of autologous cord blood in cerebral palsy

Journal of Translational Medicine

Research

Hee-Jin Kim¹  Yun Young Choi²  Hyun-Joo Jun³  Kyung Vin Choi³  Jin Hwa Moon³  Hye-Ryeong Kang³  Young-Ho Lee⁴  Jong-Hwa Lee⁵  Su Min Son⁶  Young-Jun Lee⁷  Hyung Sun Kim⁸  Mi Jung Kim⁸  Se-In Oh⁸  Jang Soo Um⁸  Soo-Jin Choi⁹  Yoon-Sun Yang⁹  Wonil Oh⁹ 

[1] Cell Therapy Center for Intractable Neurological Disorders, Hanyang University Medical Center, Seoul, South Korea;Department of Nuclear Medicine, Hanyang University Medical Center, Seoul, South Korea;Department of Pediatrics & Cord Blood Clinic, Hanyang University Medical Center, Seoul, South Korea;Department of Pediatrics & Cord Blood Clinic, Hanyang University Medical Center, Seoul, South Korea;Cell Therapy Center for Intractable Neurological Disorders, Hanyang University Medical Center, Seoul, South Korea;Department of Pediatrics, Wonkwang University Medical Center, Sanbon, South Korea;Department of Physical Medicine & Rehabilitation, Yeungnam University Medical Center, Daegu, South Korea;Department of Radiology, Hanyang University Medical Center, Seoul, South Korea;Department of Rehabilitation Medicine, Hanyang University Medical Center, Seoul, South Korea;Medipost Biomedical Research Institute, Seoul, South Korea;

关键词: Cerebral palsy;    Cord blood;    Mononuclear cells;    Cell therapy;   

DOI  :  10.1186/1479-5876-10-58

 received in 2012-01-18, accepted in 2012-03-23,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundsWe conducted a pilot study of the infusion of intravenous autologous cord blood (CB) in children with cerebral palsy (CP) to assess the safety and feasibility of the procedure as well as its potential efficacy in countering neurological impairment.MethodsPatients diagnosed with CP were enrolled in this study if their parents had elected to bank their CB at birth. Cryopreserved CB units were thawed and infused intravenously over 10~20 minutes. We assessed potential efficacy over 6 months by brain magnetic resonance imaging (MRI)-diffusion tensor imaging (DTI), brain perfusion single-photon emission computed tomography (SPECT), and various evaluation tools for motor and cognitive functions.ResultsTwenty patients received autologous CB infusion and were evaluated. The types of CP were as follows: 11 quadriplegics, 6 hemiplegics, and 3 diplegics. Infusion was generally well-tolerated, although 5 patients experienced temporary nausea, hemoglobinuria, or urticaria during intravenous infusion. Diverse neurological domains improved in 5 patients (25%) as assessed with developmental evaluation tools as well as by fractional anisotropy values in brain MRI-DTI. The neurologic improvement occurred significantly in patients with diplegia or hemiplegia rather than quadriplegia.ConclusionsAutologous CB infusion is safe and feasible, and has yielded potential benefits in children with CP.

【 授权许可】

Unknown   
© Lee et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.