Pulmonary flow profile and distensibility following acute pulmonary embolism

Journal of Cardiovascular Magnetic Resonance

Research

Soha Romeih¹  Jos JM Westenberg¹  Albert de Roos¹  Lucia JM Kroft¹  Frederikus A Klok²  Menno V Huisman² 

[1] Department of Radiology, LUMC, Leiden, the Netherlands;Section of Vascular medicine, department of General Internal Medicine-Endocrinology, LUMC, Leiden, the Netherlands;

关键词: Pulmonary Artery;    Pulmonary Embolism;    Pulmonary Hypertension;    Right Ventricular;    Cardiovascular Magnetic Resonance;   

DOI  :  10.1186/1532-429X-13-14

 received in 2010-05-18, accepted in 2011-02-18,  发布年份 2011

来源: Springer

【 摘 要 】

ObjectiveProof of concept study evaluating CMR as screening tool for chronic thromboembolic pulmonary hypertension (CTEPH) in patients treated for acute pulmonary embolism (PE).Materials and methodsRight and left ventricular function of 15 consecutive patients treated for PE and 10 consecutive patients in whom PE was excluded was estimated at baseline by cardiac CT and at 6 months follow-up by CMR. Additionally, during the follow-up visit, pulmonary artery (PA) hemodynamics were studied by CMR and the presence of pulmonary hypertension by echocardiography.ResultsCT measured right ventricular ejection fraction (RVEF) was lower in patients with PE compared to patients without PE at time of diagnosis (median 47%, interquartile range 39-53 vs. 55%, 52-58; p = 0.014). After 6 months follow up, the RVEF between patients treated for PE and patients without PE were not statistically significant different (55%, 52-60 versus 54%, 51-57; p = 0.57), as were distensibility index (0.18 ± 0.18 versus 0.25 ± 0.18, p = 0.20), mean velocity (14.1 ± 3.9 cm/s versus 14.0 ± 2.5 cm/s, p = 0.81), peak velocity (86.5 ± 22 cm/s versus 89.6 ± 13 cm/s, p = 0.43) and time to peak PA blood flow velocity (142 ± 49 ms versus 161 ± 29 ms, p = 0.14). One patient was diagnosed with CTEPH and CMR revealed poor right systolic function, decreased PA distensibility and flow velocity, and a systolic notch in the PA flow profile consistent with persistent PA obstruction.ConclusionIn this small series, right ventricular performance and PA flow profiles of patients treated for 6 months after PE are equivalent to those parameters in normal patients.

【 授权许可】

CC BY   
© Klok et al; licensee BioMed Central Ltd. 2011