Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds

Molecular Cancer

Review

Udo Schumacher¹  Timur R Samatov²  Alexander G Tonevitsky³ 

[1] Department of Anatomy and Experimental Morphology, University Cancer Center, University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246, Hamburg, Germany;SRC Bioclinicum, Ugreshskaya str 2/85, 115088, Moscow, Russia;The Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Baltiiskaya str. 8, 125315, Moscow, Russia;P.A. Hertsen Moscow Research Oncology Institute, 2nd Botkinskii p. 3, 125284, Moscow, Russia;

关键词: Alternative splicing;    Cell adhesion molecules;    Epithelial-mesenchymal transition;    Metastatic cascade;    Non-coding RNAs;    Small molecule compounds;    Transcription factors;   

DOI  :  10.1186/1476-4598-12-107

 received in 2013-04-10, accepted in 2013-09-16,  发布年份 2013

来源: Springer

【 摘 要 】

Epithelial-mesenchymal transition (EMT) is a key process in embryonic development and metastases formation during malignant progression. This review focuses on transcriptional regulation, non-coding RNAs, alternative splicing events and cell adhesion molecules regulation during EMT. Additionally, we summarize the knowledge with regard to the small potentially druggable molecules capable of modulating EMT for cancer therapy.

【 授权许可】

CC BY   
© Samatov et al.; licensee BioMed Central Ltd. 2013