Genetic variants in lipid metabolism are independently associated with multiple features of the metabolic syndrome

Lipids in Health and Disease

Research

Jolanda MA Boer¹  Cécile M Povel²  Edith JM Feskens³  Sandra Imholz⁴  Martijn ET Dollé⁴ 

[1] Centre for Nutrition and Health (CVG), National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands;Centre for Nutrition and Health (CVG), National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands;Division of Human Nutrition, Wageningen University, Wageningen, the Netherlands;Division of Human Nutrition, Wageningen University, Wageningen, the Netherlands;Laboratory for Health Protection Research (GBO), National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands;

关键词: HDL-cholesterol;    abdominal obesity;    metabolic syndrome;    CETP;    APOE;   

DOI  :  10.1186/1476-511X-10-118

 received in 2011-06-02, accepted in 2011-07-18,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundOur objective was to find single nucleotide polymorphisms (SNPs), within transcriptional pathways of glucose and lipid metabolism, which are related to multiple features of the metabolic syndrome (MetS).Methods373 SNPs were measured in 3575 subjects of the Doetinchem cohort. Prevalence of MetS features, i.e. hyperglycemia, abdominal obesity, decreased HDL-cholesterol levels and hypertension, were measured twice in 6 years. Associations between the SNPs and the individual MetS features were analyzed by log-linear models. For SNPs related to multiple MetS features (P < 0.01), we investigated whether these associations were independent of each other.ResultsTwo SNPs, CETP Ile405Val and APOE Cys112Arg, were associated with both the prevalence of low HDL-cholesterol level (Ile405Val P = < .0001; Cys112Arg P = 0.001) and with the prevalence of abdominal obesity (Ile405Val P = 0.007; Cys112Arg P = 0.007). For both SNPs, the association with HDL-cholesterol was partly independent of the association with abdominal obesity and vice versa.ConclusionTwo SNPs, mainly known for their role in lipid metabolism, were associated with two MetS features i.e., low HDL-cholesterol concentration, as well as, independent of this association, abdominal obesity. These SNPs may help to explain why low HDL-cholesterol levels and abdominal obesity frequently co-occur.

【 授权许可】

CC BY   
© Povel et al; licensee BioMed Central Ltd. 2011