Immunological consequences of intermittent preventive treatment against malaria in Senegalese preschool children

Malaria Journal

Research

Cheikh Sokhna¹  Jean-François Trape¹  Franck Remoué²  François Simondon³  Anne-Marie Schacht⁴  Brian Greenwood⁵  Jean Biram Sarr⁶  Gilles Riveau⁶  Florie Fillol⁷  Denis Boulanger⁷  Badara Cisse⁸ 

[1] IRD, UMR198, Route des Pères Maristes, BP 1386, 18524, Dakar, Sénégal;IRD, UR016, BP64501, 34394, Montpellier, 911 avenue Agropolis, France;IRD-UR024, Montpellier, France;Immunology and Infection Center of Lille, Pasteur Institute of Lille, France;London School of Hygiene & Tropical Medicine, London, United-Kingdom;ONG Espoir Pour La Santé (EPLS), BP 226, Saint-Louis, Sénégal;Unité Mixte de Recherche 145, Institut de Recherche pour le Développement and Université Montpellier 1, BP64501, 911 avenue Agropolis, 34394, Montpellier, France;Université Cheikh Anta Diop, Département de Parasitologie, Dakar, Sénégal;

关键词: Malaria;    Artesunate;    Entomological Inoculation Rate;    Transmission Season;    Intermittent Preventive Treatment;   

DOI  :  10.1186/1475-2875-9-363

 received in 2010-06-15, accepted in 2010-12-17,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundIntermittent preventive treatment in children (IPTc) is a promising strategy to control malaria morbidity. A significant concern is whether IPTc increases children's susceptibility to subsequent malaria infection by altering their anti-Plasmodium acquired immunity.MethodsTo investigate this concern, IgG antibody (Ab) responses to Plasmodium falciparum schizont extract were measured in Senegalese children (6 months-5 years old) who had received three rounds of IPTc with artesunate + sulphadoxine-pyrimethamine (or placebo) at monthly intervals eight months earlier. Potential confounding factors, such as asexual malaria parasitaemia and nutritional status were also evaluated.ResultsFirstly, a bivariate analysis showed that children who had received IPTc had lower anti-Plasmodium IgG Ab levels than the non-treated controls. When epidemiological parameters were incorporated into a multivariate regression, gender, nutritional status and haemoglobin concentration did not have any significant influence. In contrast, parasitaemia, past malaria morbidity and increasing age were strongly associated with a higher specific IgG response.ConclusionsThe intensity of the contacts with P. falciparum seems to represent the main factor influencing anti-schizont IgG responses. Previous IPTc does not seem to interfere with this parasite-dependent acquired humoral response eight months after the last drug administration.

【 授权许可】

CC BY   
© Boulanger et al; licensee BioMed Central Ltd. 2010