Is radical radiotherapy with/without surgery an effective treatment in the lymphoepithelial carcinoma of the salivary gland？

BMC Cancer

Research

Xiaoshen Wang¹  Peiyao Liu²  Chaosu Hu²  Xiaoshuang Niu² 

[1] Department of Radiation Oncology, Eye & ENT Hospital, Fudan University, Shanghai, China;Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China;Department of Oncology, Shanghai Medical College, Fudan University, 200032, Shanghai, China;Department of Radiation Oncology, Shanghai Clinical Research Center for Radiation Oncology, Shanghai, China;Shanghai Key Laboratory of Radiation Oncology, Shanghai, China;

关键词: Lymphoepithelial carcinoma;    Salivary gland;    Radical radiotherapy;    Surgery;    Effective treatment;   

DOI  :  10.1186/s12885-023-11466-1

 received in 2023-06-07, accepted in 2023-09-29,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThere is limited information of radical radiotherapy (RT) on lymphoepithelial carcinoma of salivary gland (LECSG) regarding to the rarity of the disease. We conducted this retrospective study that evaluated the feasibility and efficacy of radical RT with/without surgery in LECSG.MethodsWe retrospectively reviewed patients that were pathologically diagnosed of LECSG and had definite or suspicious residual disease. The prescribed dose given to P-GTV and/or P-GTV-LN was 66 to 70.4 Gy. The clinical target volume (CTV) involved ipsilateral salivary gland and corresponding lymph node drainage area.ResultsA total of 56 patients were included. With a median follow-up of 60 months (range: 8 to 151 months), the 1-, 5-, and 10-year progression-free survival (PFS) rates were 94.6%, 84.7% and 84.7%; locoregional progression-free survival (LRPFS) rates were 98.2%, 87.4% and 87.4%; distance metastasis-free survival (DMFS) rates were 94.6%, 86.7% and 86.7%; and overall survival (OS) rates were 98.2%, 92.4% and 89.0%, respectively. A total of 7 patients without surgery were included. All patients were alive and only one patient experienced failure of distant metastasis four months after RT. The results of univariate analysis showed that compared with N stage, the number of positive lymph nodes (2 positive lymph nodes) was better prognostic predictor especially in PFS. There were no treatment-related deaths and most toxicities of RT were mild.ConclusionsRadical RT with/without surgery in LECSG for definite or suspicious residual disease is feasibility and efficacy. Most toxicities of RT were mild due to the target volume involved ipsilateral area.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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