Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria

Malaria Journal

Review

Frank M Smithuis¹  Michael J Delves²  Andrea Ruecker²  Alice C Eziefula³  Teun Bousema³  Chris Drakeley³  Elizabeth A Ashley⁴  Judith Recht⁴  Nicholas J White⁵  Kesinee Chotivanich⁶  Sasithon Pukrittayakamee⁶  Mallika Imwong⁷  Cindy Chu⁸  Chiara Andolina⁸  Germana Bancone⁸  Jetsumon Prachumsri⁹  Tran T Hien^1,10 

[1] Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK;Myanmar Oxford Clinical Research Unit, Yangon, Myanmar;Department of Life Sciences, Imperial College, London, UK;London School of Hygiene and Tropical Medicine, London, UK;Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK;Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;Shoklo Malaria Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Tak, Thailand;Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam;

关键词: Malaria;    Falciparum Malaria;    Artesunate;    Primaquine;    Gametocyte Carriage;   

DOI  :  10.1186/1475-2875-13-483

 received in 2014-11-08, accepted in 2014-11-29,  发布年份 2014

来源: Springer

【 摘 要 】

Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies.

【 授权许可】

CC BY   
© White et al.; licensee BioMed Central. 2014