Hysteretic behavior of bladder afferent neurons in response to changes in bladder pressure

BMC Neuroscience

Research Article

Tim M. Bruns¹  Shani E. Ross²  Zachariah J. Sperry³  Colin M. Mahar⁴ 

[1] Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA;Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA;NCRC-B10-A169, 2800 Plymouth Road, 48109, Ann Arbor, MI, USA;Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA;Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA;NCRC-B20-104W, 2800 Plymouth Road, 48109, Ann Arbor, MI, USA;Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA;Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA;NCRC-B20-111WD, 2800 Plymouth Road, 48109, Ann Arbor, MI, USA;Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, MI, USA;Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA;NCRC-B20-111WD, 2800 Plymouth Road, 48109, Ann Arbor, MI, USA;

关键词: Hysteresis;    Dorsal root ganglia;    Bladder afferents;    Pelvic nerve;    Urinary tract;    Bladder;    Bladder pressure;   

DOI  :  10.1186/s12868-016-0292-5

 received in 2016-03-10, accepted in 2016-08-01,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundMechanosensitive afferents innervating the bladder increase their firing rate as the bladder fills and pressure rises. However, the relationship between afferent firing rates and intravesical pressure is not a simple linear one. Firing rate responses to pressure can differ depending on prior activity, demonstrating hysteresis in the system. Though this hysteresis has been commented on in published literature, it has not been quantified.ResultsSixty-six bladder afferents recorded from sacral dorsal root ganglia in five alpha-chloralose anesthetized felines were identified based on their characteristic responses to pressure (correlation coefficient ≥ 0.2) during saline infusion (2 ml/min). For saline infusion trials, we calculated a maximum hysteresis ratio between the firing rate difference at each pressure and the overall firing rate range (or Hmax) of 0.86 ± 0.09 (mean ± standard deviation) and mean hysteresis ratio (or Hmean) of 0.52 ± 0.13 (n = 46 afferents). For isovolumetric trials in two experiments (n = 33 afferents) Hmax was 0.72 ± 0.14 and Hmean was 0.40 ± 0.14.ConclusionsA comprehensive state model that integrates these hysteresis parameters to determine the bladder state may improve upon existing neuroprostheses for bladder control.

【 授权许可】

CC BY   
© The Author(s) 2016