Associations of sex hormone-binding globulin and testosterone with diabetes among men and women (the Saku Diabetes study): a case control study

Cardiovascular Diabetology

Original Investigation

Mitsuhiko Noda¹  Maki Goto²  Atsushi Goto²  Yasuo Terauchi³  Naomi Aiba⁴  Satoshi Sasaki⁵  Shaw Watanabe⁶  Motohiko Miyachi⁶  Akemi Morita⁷ 

[1] Department of Diabetes Research, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan;Department of Diabetes and Metabolic Medicine, Center Hospital, National Center for Global Health and Medicine, Tokyo, Japan;Department of Diabetes and Metabolic Medicine, Center Hospital/Department of Diabetes Research, Diabetes Research Center, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, 162-8655, Tokyo, Japan;Department of Diabetes Research, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan;National Institute of Health and Nutrition, Tokyo, Japan;Department of Endocrinology and Metabolism, Yokohama City University Graduate School of Medicine, Kanagawa, Japan;Department of Endocrinology and Metabolism, Yokohama City University Graduate School of Medicine, Kanagawa, Japan;Department of Nutrition and Life Science, Kanagawa Institute of Technology, Kanagawa, Japan;Department of Social and Preventive Epidemiology, School of Public Health, University of Tokyo, Tokyo, Japan;National Institute of Health and Nutrition, Tokyo, Japan;National Institute of Health and Nutrition, Tokyo, Japan;Department of Nutrition, College of Nutrition, Koshien University, Hyogo, Japan;

关键词: Sex hormone;    Sex hormone-binding globulin;    Sex difference;    Fatty liver disease;   

DOI  :  10.1186/1475-2840-11-130

 received in 2012-09-09, accepted in 2012-10-13,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundSex hormone-binding globulin (SHBG) levels and sex hormones have been implicated in the pathogenesis of type 2 diabetes and cardiovascular diseases. As fatty liver has been suggested to be a major determinant of SHBG levels, we examined whether the associations of SHBG and testosterone with diabetes were independent of fatty liver.MethodsWe conducted a case–control study that included 300 diabetes cases (215 men and 85 women) and 300 matched controls from the Saku cohort study. Diabetes was defined by either fasting plasma glucose levels ≥126 mg/dL, 2-h post-load glucose levels ≥200 mg/dL after a 75 g oral glucose tolerance test, or diabetes diagnosed by physicians. We fitted conditional logistic regression models to examine the associations between SHBG and total testosterone levels with diabetes by sex. To evaluate the impact of fatty liver, we used the fatty liver index (FLI), a validated measure derived from serum triglyceride levels, body mass index (BMI), waist circumference, and γ-glutamyltransferase levels.ResultsAfter adjusting for age, family history of diabetes, smoking, physical activity, BMI, and FLI, SHBG levels were inversely associated with diabetes among women (odds ratio [OR] comparing the highest with the lowest quartiles, 0.13 [95% confidence interval {CI}, 0.02–0.96]), but not among men. Similar patterns were observed in a subgroup analysis restricted to postmenopausal women"(OR, 0.12 [95% CI, 0.01–1.17]). In contrast, testosterone levels were inversely associated with diabetes among men (OR, 0.45 [95% CI, 0.23–0.89]), but not among women.ConclusionsOur findings suggest that SHBG in women and testosterone in men may be inversely associated with diabetes.

【 授权许可】

Unknown   
© Goto et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.