MicroRNA modulators of epigenetic regulation, the tumor microenvironment and the immune system in lung cancer

Molecular Cancer

Review

Jacek Niklinski¹  Anna Maria Rusek²  Mohammed Abba³  Heike Allgayer³  Andrzej Eljaszewicz⁴  Marcin Moniuszko⁴ 

[1] Department of Clinical Molecular Biology, Medical University of Bialystok, Waszyngtona 13, 15-269, Białystok, Poland;Department of Clinical Molecular Biology, Medical University of Bialystok, Waszyngtona 13, 15-269, Białystok, Poland;Department of Experimental Surgery, Medical Faculty Mannheim, Heidelberg University, Theodor Kutzer Ufer 1-3, 68135, Mannheim, Germany;Molecular Oncology of Solid Tumors, DKFZ (German Cancer Research Centre), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany;Department of Experimental Surgery, Medical Faculty Mannheim, Heidelberg University, Theodor Kutzer Ufer 1-3, 68135, Mannheim, Germany;Molecular Oncology of Solid Tumors, DKFZ (German Cancer Research Centre), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany;Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Bialystok, Waszyngtona 13, 15-269, Białystok, Poland;

关键词: microRNA;    Lung cancer;    Epigenetic regulation;    Tumor microenvironment;   

DOI  :  10.1186/s12943-015-0302-8

 received in 2014-08-26, accepted in 2015-01-21,  发布年份 2015

来源: Springer

【 摘 要 】

Cancer is an exceedingly complex disease that is orchestrated and driven by a combination of multiple aberrantly regulated processes. The nature and depth of involvement of individual events vary between cancer types, and in lung cancer, the deregulation of the epigenetic machinery, the tumor microenvironment and the immune system appear to be especially relevant. The contribution of microRNAs to carcinogenesis and cancer progression is well established with many reports and investigations describing the involvement of microRNAs in lung cancer, however most of these studies have concentrated on single microRNA-target relations and have not adequately addressed the complexity of their interactions. In this review, we focus, in part, on the role of microRNAs in the epigenetic regulation of lung cancer where they act as active molecules modulating enzymes that take part in methylation-mediated silencing and chromatin remodeling. Additionally, we highlight their contribution in controlling and modulating the tumor microenvironment and finally, we describe their role in the critical alteration of essential molecules that influence the immune system in lung cancer development and progression.

【 授权许可】

Unknown   
© Rusek et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.