Vitamin D and biomarkers of inflammation and oxidative stress among pregnant women: a systematic review of observational studies

BMC Immunology

Research

Soudabe Motamed¹  Reza Amani²  Razieh Anari³  Somayeh Motamed⁴ 

[1] Asadabad School of Medical Sciences, Asadabad, Iran;Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran;National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran;School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;

关键词: 25-hydroxyvitamin D;    Vitamin D;    Inflammation;    Oxidative stress;    Pregnancy;    Systematic review;   

DOI  :  10.1186/s12865-023-00577-w

 received in 2023-09-06, accepted in 2023-10-16,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectiveThis systematic review aimed to map the evidence evaluated the relationship between vitamin D and redox and inflammatory status during gestation.MethodsThree databases (PubMed/MEDLINE, Scopus, and Web of Science (WoS)) and reference list of included documents were searched for related observational studies published until 2nd October 2023. To determine the quality of the selected observational studies, the Newcastle-Ottawa Scale (NOS) was used.ResultsAfter a primary search of three databases, 19492records were appeared. When duplicates and irrelevant documents were removed, 14 articles were found to have eligible criteria. The design of the identified studies was cross-sectional, case-control and cohort. Evidence showed an adverse association between 25(OH)D and the biomarkers of inflammation, such as high-sensitivity C-reactive protein (hs-CRP), Interleukin-1beta (IL-1β), Interleukin-6 (IL-6), and tumor necrosis factor- alfa (TNF-α) during pregnancy. On the contrary, some studies represented that 25(OH)D positively correlated with hs-CRP in the cord blood. One study suggested a direct association between serum concentrations of 25(OH)D and Interleukin-8 (IL-8), macrophage inflammatory protein (MIP), and TNF-α levels in mothers with gestational diabetes mellitus (GDM). A case-control study showed that lower serum concentration of 25(OH)D positively correlated with total antioxidant capacity (TAC) levels in participants.ConclusionsEvidence confirmed the supposition of the direct relationship between vitamin D levels and biomarkers with anti-inflammatory and anti-oxidative properties. However, the Existence of inconsistent evidence confirms the need for further studies in mothers with GDM and hypertensive disorders.PROSPERO registration codeCRD42020202600.

【 授权许可】

CC BY   
© The Author(s) 2023

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