Highly automatic quantification of myocardial oedema in patients with acute myocardial infarction using bright blood T2-weighted CMR

Journal of Cardiovascular Magnetic Resonance

Technical Notes

Alexander R Payne¹  Colin Berry¹  Kushsairy Kadir²  John Soraghan²  Hao Gao³ 

[1] BHF Glasgow Cardiovascular Research Centre, University of Glasgow, G12 8TA, Glasgow, UK;Centre for Excellence in Signal and Image Processing, Department of Electrical Engineering, University of Strathclyde, G1 1XW, Glasgow, UK;School of Mathematics and Statistics, University of Glasgow, G12 8QW, Glasgow, UK;

关键词: Myocardial oedema;    Bright blood T2-weighted CMR;    Rayleigh-Gaussian mixture model;    Level set;   

DOI  :  10.1186/1532-429X-15-28

 received in 2012-08-01, accepted in 2013-03-18,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundT2-weighted cardiovascular magnetic resonance (CMR) is clinically-useful for imaging the ischemic area-at-risk and amount of salvageable myocardium in patients with acute myocardial infarction (MI). However, to date, quantification of oedema is user-defined and potentially subjective.MethodsWe describe a highly automatic framework for quantifying myocardial oedema from bright blood T2-weighted CMR in patients with acute MI. Our approach retains user input (i.e. clinical judgment) to confirm the presence of oedema on an image which is then subjected to an automatic analysis. The new method was tested on 25 consecutive acute MI patients who had a CMR within 48 hours of hospital admission. Left ventricular wall boundaries were delineated automatically by variational level set methods followed by automatic detection of myocardial oedema by fitting a Rayleigh-Gaussian mixture statistical model. These data were compared with results from manual segmentation of the left ventricular wall and oedema, the current standard approach.ResultsThe mean perpendicular distances between automatically detected left ventricular boundaries and corresponding manual delineated boundaries were in the range of 1-2 mm. Dice similarity coefficients for agreement (0=no agreement, 1=perfect agreement) between manual delineation and automatic segmentation of the left ventricular wall boundaries and oedema regions were 0.86 and 0.74, respectively.ConclusionCompared to standard manual approaches, the new highly automatic method for estimating myocardial oedema is accurate and straightforward. It has potential as a generic software tool for physicians to use in clinical practice.

【 授权许可】

Unknown   
© Gao et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.