Incidence of skin and soft tissue infections in ambulatory and inpatient settings, 2005–2010

BMC Infectious Diseases

Research Article

Yan Wang¹  Honghu Liu²  Chun-Lan Chang³  Anna Wallace³  Debra F. Eisenberg³  Rakesh Luthra³  Christy Fang³  Joseph Singer³  Loren G. Miller⁴  Jose A. Suaya⁵ 

[1] Department of Biostatistics, Fielding School of Public Health at UCLA, Los Angeles, USA;Division of Public Health, School of Dentistry at UCLA, Los Angeles, USA;Division of General Internal Medicine, David Geffen School of Medicine at UCLA, Los Angeles, USA;Department of Biostatistics, Fielding School of Public Health at UCLA, Los Angeles, USA;HealthCore, Inc, Wilmington, DE, USA;Infectious Disease Clinical Outcomes Research Unit (ID-CORE), Division of Infectious Diseases, Los Angeles BioMedical Research Center at Harbor-UCLA, Torrance, CA, USA;Division of Infectious Diseases, Harbor-UCLA Medical Center, 1000 W Carson St Box 466, 90509, Torrance, CA, USA;David Geffen School of Medicine at UCLA, Los Angeles, USA;U.S. Health Outcomes, GlaxoSmithKline, Research Triangle Park, Philadelphia, PA, USA;U.S. Health Outcomes, NACMA, Vaccines, GlaxoSmithKline, PA, Philadelphia, USA;

关键词: Mastitis;    Soft Tissue Infection;    Necrotizing Fasciitis;    Veteran Administration;    National Ambulatory Medical Care Survey;   

DOI  :  10.1186/s12879-015-1071-0

 received in 2014-11-05, accepted in 2015-07-30,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThe emergence of community-associated methicillin-resistant S. aureus was associated with dramatically increased skin and soft tissue infection (SSTI) incidence in the first few years of the 21st century in the U.S. However, subsequent trends are poorly understood.MethodsWe examined ambulatory and inpatient data of over 48 million persons years aged 0–64 years from the HealthCore Integrated Research Database (HIRD) between 2005 and 2010. Data were extracted from medical, pharmacy, and eligibility databases. We quantified SSTI incidence, type, and complications and comparative incidence trends for urinary tract infections (UTIs) and pneumonia.ResultsA total of 2,301,803 SSTIs were identified. Most SSTIs (95 %) were treated in the ambulatory setting and most (60 %) were categorized as abscesses or cellulitis. During the study period, SSTI incidence remained relatively stable from 47.9 (95 % CI: 47.8–48.1) cases/1,000 PY in 2005 to 48.5 cases/1,000 PY (95 % CI: 48.3–48.6) in 2010). Persons aged 45–64 years had the highest incidence of both ambulatory-treated and inpatient-treated SSTIs (51.2 (95 % CI: 51.1–51.3) and 3.87 (95 % CI: 3.84–3.90) cases/1,000 PY, respectively). SSTI complications such as myositis, gangrene, and sepsis occurred in 0.93 % (95 % CI: 0.92–0.94 %) and 16.92 % (95 % CI: 16.87–16.97 %) of ambulatory-treated and inpatient-treated patients, respectively. SSTI incidence was approximately twice that of UTIs and tenfold of that of pneumonia.ConclusionsAmong our large, diverse population of persons less than 65 years, SSTI incidence 2005 through 2010 has remained relatively constant at approximately 4.8 SSTIs per 100 person years, suggesting that previously observed increases in SSTI incidence remain sustained.

【 授权许可】

CC BY   
© Miller et al. 2015