PPARγ Pro12Ala and ACE ID polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome

Cardiovascular Diabetology

Original Investigation

Mario Luca Morieri¹  Cristina Bosi¹  Renato Fellin¹  Edoardo Dalla Nora¹  Francesca Di Vece¹  Caterina Marcello¹  Giovanni Zuliani¹  Juana M Sanz¹  Angela Passaro¹ 

[1] Department of Clinical and Experimental Medicine, Section of Internal Medicine, Gerontology and Clinical Nutrition, University of Ferrara, Ferrara, Italy;

关键词: PPARγ2;    Pro12Ala;    ACE I/D;    polymorphism;    Metabolic Syndrome;    obesity;    fat distribution;   

DOI  :  10.1186/1475-2840-10-112

 received in 2011-08-09, accepted in 2011-12-14,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundMetabolic Syndrome (MetS) results from the combined effect of environmental and genetic factors. We investigated the possible association of peroxisome proliferator-activated receptor-γ2 (PPARγ2) Pro12Ala and Angiotensin Converting Enzyme (ACE) I/D polymorphisms with MetS and interaction between these genetic variants.MethodsThree hundred sixty four unrelated Caucasian subjects were enrolled. Waist circumference, blood pressure, and body mass index (BMI) were recorded. Body composition was estimated by impedance analysis; MetS was diagnosed by the NCEP-ATPIII criteria. A fasting blood sample was obtained for glucose, insulin, lipid profile determination, and DNA isolation for genotyping.ResultsThe prevalence of MetS did not differ across PPARγ2 or ACE polymorphisms. Carriers of PPARγ2 Ala allele had higher BMI and fat-mass but lower systolic blood pressure compared with Pro/Pro homozygotes. A significant PPARγ2 gene-gender interaction was observed in the modulation of BMI, fat mass, and blood pressure, with significant associations found in women only. A PPARγ2-ACE risk genotype combination for BMI and fat mass was found, with ACE DD/PPARγ2 Ala subjects having a higher BMI (p = 0.002) and Fat Mass (p = 0.002). Pro12Ala was independently associated with waist circumference independent of BMI and gender.ConclusionsCarriers of PPARγ2 Ala allele had higher BMI and fat-mass but not a worse metabolic profile, possibly because of a more favorable adipose tissue distribution. A gene interaction exists between Pro12Ala and ACE I/D on BMI and fat mass. Further studies are needed to assess the contribution of Pro12Ala polymorphism in adiposity distribution.

【 授权许可】

CC BY   
© Passaro et al; licensee BioMed Central Ltd. 2011