Can surgical management of bone metastases improve quality of life among women with gynecologic cancer?

World Journal of Surgical Oncology

Research

Ramez Eskander¹  Bang H Hoang²  Kunkun Sun³  Wei Guo⁴  Yifei Wang⁴  Tao Ji⁵ 

[1] Department of Obsterics and Gynecology, Division of Gynecologic Oncology, University of California Irvine Medical Center, 92868, Orange, CA, USA;Department of Orthopaedic Surgery and Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, 92868, Orange, CA, USA;Department of Pathology, People’s Hospital, Peking University, 100044, Beijing, China;Musculoskeletal Tumor Center, People’s Hospital, Peking University, 100044, Beijing, China;Musculoskeletal Tumor Center, People’s Hospital, Peking University, 100044, Beijing, China;Department of Orthopaedic Surgery and Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, 92868, Orange, CA, USA;

关键词: gynecological cancer;    bone metastasis;    surgery;    quality of life;    palliative treatment;   

DOI  :  10.1186/1477-7819-12-250

 received in 2014-01-30, accepted in 2014-07-20,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe evaluation, counseling, and management of gynecologic patients with bone metastasis remain a challenge for clinicians. In order to critically evaluate the role of surgery, we retrospectively analyzed the records of 18 patients surgically treated for metastatic gynecologic tumors of bone, focusing on quality of life, local tumor control, and survival.MethodsEighteen patients underwent surgical procedures for the treatment of bone metastases secondary to gynecologic cancer between September 2003 and April 2012. The primary cancer sites included the uterus (n = 10), the cervix (n = 5), and an ovary (n = 3). Patients were followed for an average period of 13.8 months (range, 2 to 34 months). A visual analog pain scale (VAS) and Eastern Cooperative Oncology Group (ECOG) performance status were evaluated both pre- and postoperatively.ResultsThe median survival time following diagnosis of bone metastasis was 10.0 months. The mean VAS score was 5.8 preoperatively compared with 2.1, 3 months after surgery. The mean pre and postoperative ECOG performance status grades were 3.1 and 2.3, respectively.ConclusionsThe prognosis of gynecological cancer patients with bone metastasis is poor. Some patients had improvement in their quality of life after surgical intervention for bone metastases; however, novel integrated treatment modalities should be investigated.

【 授权许可】

Unknown   
© Ji et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.