Plasmacytoid variant of bladder cancer defines patients with poor prognosis if treated with cystectomy and adjuvant cisplatin-based chemotherapy

BMC Cancer

Research Article

Robert Stoehr¹  Arndt Hartmann¹  Simone Bertz¹  Michael Stöckle²  Bastian Keck³  Frank Kunath³  Helge Taubert³  Sven Wach³  Bernd Wullich³  Jan Lehmann⁴ 

[1] Department of Pathology, University Erlangen, Krankenhausstr 8-10, 91054, Erlangen, Germany;Department of Urology, Saarland University, Kirrberger Straße, 66421, Homburg/Saar, Germany;Department of Urology, University Erlangen, Krankenhausstraße 12, 91054, Erlangen, Germany;Urology Practice, Prüner Gang, Prüner Gang 15, 24103, Kiel, Germany;

关键词: Chemotherapy;    Cystectomy;    Micropapillary;    Plasmacytoid;    Prognosis;    Urinary bladder neoplasm;   

DOI  :  10.1186/1471-2407-13-71

 received in 2012-08-16, accepted in 2013-01-30,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundSince the definition of different histologic subtypes of urothelial carcinomas by the World Health Organization (WHO) 2004 classification, description of molecular features and clinical behavior of these variants has gained more attention.MethodsWe reviewed 205 tumor samples of patients with locally advanced bladder cancer mainly treated within the randomized AUO-AB05/95 trial with radical cystectomy and adjuvant cisplatin-based chemotherapy for histologic subtypes. 178 UC, 18 plasmacytoid (PUC) and 9 micropapillary (MPC) carcinomas of the bladder were identified. Kaplan Meier analysis and backward multivariate Cox’s proportional hazards regression analysis were performed to compare overall survival between the three histologic subtypes.ResultsPatients suffering from PUC have the worst clinical outcome regarding overall survival compared to conventional UC and MPC of the bladder that in turn seem have to best clinical outcome (27.4 months, 62.6 months, and 64.2 months, respectively; p=0.013 by Kaplan Meier analysis). Backward multivariate Cox´s proportional hazards regression analysis (adjusted to relevant clinicopathological parameters) showed a hazard ratio of 3.2 (p=0.045) for PUC in contrast to patients suffering from MPC.ConclusionsHistopathological diagnosis of rare variants of urothelial carcinoma can identify patients with poor prognosis.

【 授权许可】

CC BY   
© Keck et al.; licensee BioMed Central Ltd. 2013