Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults

Nutrition Journal

Research

Diogo Van Bavel¹  Eduardo Tibiriçá¹  Beatriz Serpa de Moraes¹  Roger de Moraes² 

[1] National Institute of Cardiology (INC), 21045-900, Rio de Janeiro, Brazil;Laboratory of Cardiovascular Investigation, Oswaldo Cruz Institute, Rio de Janeiro, Brazil;National Institute of Cardiology (INC), 21045-900, Rio de Janeiro, Brazil;Laboratory of Cardiovascular Investigation, Oswaldo Cruz Institute, Rio de Janeiro, Brazil;School of Physical Education and Sports Sciences, of the Estácio de Sá University, Rio de Janeiro, Brazil;

关键词: Laser speckle contrast imaging;    Intra-vital video-microscopy;    Capillary recruitment;    Post-occlusive reactive hyperemia;   

DOI  :  10.1186/1475-2891-13-115

 received in 2014-10-16, accepted in 2014-12-09,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundDietary creatine supplementation (CrS) is a practice commonly adopted by physically active individuals. However, the effects of CrS on systemic microvascular reactivity and density have never been reported. Additionally, CrS is able to influence blood levels of homocysteine, resulting in presumed effects on vascular endothelial function. Thus, we investigated the effects of CrS on the systemic microcirculation and on homocysteine levels in healthy young individuals.MethodsThis open-label study was performed on a group of 40 healthy male, moderately physically active subjects aged 27.7 ± 13.4 years who received one week of CrS at a dose of 20 g/day of commercially available micronized creatine monohydrate. Laser speckle contrast imaging was used in the evaluation of cutaneous microvascular reactivity, and intra-vital video microscopy was used to evaluate skin capillary density and reactivity, before and after CrS.ResultsCrS did not alter plasma levels of homocysteine, although CrS increased creatinine (p = 0.0001) and decreased uric acid (p = 0.0004) plasma levels. Significant changes in total cholesterol (p = 0.0486) and LDL-cholesterol (p = 0.0027) were also observed along with a reduction in plasma levels of T3 (p = 0.0074) and an increase in T4 levels (p = 0.0003). Skin functional capillary density (p = 0.0496) and capillary recruitment during post-occlusive reactive hyperemia (p = 0.0043) increased after CrS. Increases in cutaneous microvascular vasodilation induced by post-occlusive reactive hyperemia (p = 0.0078) were also observed.ConclusionsOral supplementation with creatine in healthy, moderately physically active young adults improves systemic endothelial-dependent microvascular reactivity and increases skin capillary density and recruitment. These effects are not concurrent with changes in plasma homocysteine levels.

【 授权许可】

Unknown   
© de Moraes et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.