Low HDL cholesterol is correlated to the acute ischemic stroke with diabetes mellitus

Lipids in Health and Disease

Research

Yun Xu¹  Jingwei Li¹  Yun Luo²  Junfeng Zhang³ 

[1] Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, 210008, Nanjing, China;Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, 210008, Nanjing, China;School of Life Science, Nanjing University, 210093, Nanjing, China;School of Life Science, Nanjing University, 210093, Nanjing, China;

关键词: Diabetes mellitus;    Ischemic stroke;    High density lipoprotein cholesterol;   

DOI  :  10.1186/1476-511X-13-171

 received in 2014-08-22, accepted in 2014-10-21,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundTo clarify the role of lipid composition in the occurrence of acute ischemic stroke (AIS) with diabetes mellitus (DM) and its influence factors.MethodsData was collected from the patients hospitalization in Affiliated Drum Tower Hospital of Nanjing University Medical School from October 2008 to May 2012, which included AIS and non-AIS consist of transient ischemic attack (TIA) and Vertigo or dizzy. Lipid and other risk factors including blood glucose (BG), uric acid (UA), hypertension, DM and atrial fibrillation (AF) were investigated in relation to occurrence of AIS.ResultsThe level of high density lipoprotein (HDL) cholesterol was decreased obviously in the DM group compared to the non-DM group and low level of HDL cholesterol was prevalent in the AIS patients with DM. logistic regression demonstrated that decreased HDL cholesterol was correlated to the AIS with DM, not all AIS, and the relative risk of ischemic stroke in low HDL cholesterol level group was 2.113 (95% CI = 1.191-3.749, P = 0.011) compared to the high level group. Furthermore, age has the obviously impact on it. HDL cholesterol was correlated to the AIS with DM just in the populations of aged ≦70 years (OR = 0.192, P = 0.000), low level of HDL cholesterol had more high risk of ischemic stroke than that in the high level group (OR = 6.818, P = 0.002).ConclusionDecreased HDL cholesterol was correlated to the occurrence of AIS with DM, especially in the populations of aged ≦70 years.

【 授权许可】

Unknown   
© Luo et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.