Acute and chronic animal models for the evaluation of anti-diabetic agents

Cardiovascular Diabetology

Review

Suresh Kumar¹  Rajeshwar Singh¹  Neeru Vasudeva¹  Sunil Sharma¹ 

[1] Pharmacology Division, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Post Box: 38, 125001, Hisar, India;

关键词: Streptozotocin;    alloxan;    diabetic rats;    animal models;    diabetes;   

DOI  :  10.1186/1475-2840-11-9

 received in 2011-11-21, accepted in 2012-01-19,  发布年份 2012

来源: Springer

【 摘 要 】

Diabetes mellitus is a potentially morbid condition with high prevalence worldwide thus being a major medical concern. Experimental induction of diabetes mellitus in animal models is essential for the advancement of our knowledge and understanding of the various aspects of its pathogenesis and ultimately finding new therapies and cure. Experimental diabetes mellitus is generally induced in laboratory animals by several methods that include: chemical, surgical and genetic (immunological) manipulations. Most of the experiments in diabetes are carried out in rodents, although some studies are still performed in larger animals. The present review highlights the various methods of inducing diabetes in experimental animals in order to test the newer drugs for their anti-diabetic potential.

【 授权许可】

CC BY   
© Kumar et al; licensee BioMed Central Ltd. 2012