Lipid-related residual risk and renal function for occurrence and prognosis among patients with first-event acute coronary syndrome and normal LDL cholesterol

Lipids in Health and Disease

Research

Hung-Ju Lin¹  Hsiu-Ching Hsu¹  Ming-Fong Chen¹  Kuo-Liong Chien² 

[1] Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;Institute of Epidemiology & Preventive Medicine, National Taiwan University, Taipei, Taiwan;Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;

关键词: acute coronary syndrome;    residual risk;    dyslipidemia;   

DOI  :  10.1186/1476-511X-10-215

 received in 2011-10-12, accepted in 2011-11-19,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundWe investigated relationship of low levels of high density lipoprotein cholesterol (HDL-C), high levels of triglycerides, and renal function for the odds, prognosis and survival following acute coronary events among patients with a first event and normal low density lipoprotein cholesterol levels.ResultsA case-control study based on 557 patients and 1086 matched control subjects was conducted. Case patients were followed up for survival with a median of 1.9 years. Participants in the higher quintiles of HDL-C had lower odds to develop acute coronary events (the adjusted odds ratios were 0.24 for the second, 0.24 for the third, 0.10 for the fourth and 0.05 for the fifth quintile). Patients with normal glomerular filtration rate were at a lower risk for all-cause death. However, a reverse association between triglycerides and death risk was found: patients with higher triglycerides were at a lower risk for all-cause death (adjusted relative risk, 0.38 for triglycerides ranging from 82 to 132.9 mg/dL, and 0.14 for triglycerides > = 133 mg/dL).ConclusionsLow HDL-C was significantly associated with acute coronary events, and triglyceride levels as well as renal function were inversely related to all-cause deaths after the coronary event.

【 授权许可】

CC BY   
© Chien et al; licensee BioMed Central Ltd. 2011