Sudden onset of parathyroid hormone-independent severe hypercalcemia from reversal of tumoral calcinosis in a dialysis patient

BMC Nephrology

Case Report

Gregory Kline¹  Fareed B. Kamar¹  Bikaramjit Mann² 

[1] Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;

关键词: Hypercalcemia;    Parathyroid hormone;    Hyperparathyroidism;    Tumoral calcinosis;    Metastatic calcification;    Chronic kidney disease;    Peritoneal dialysis;    Hemodialysis;   

DOI  :  10.1186/s12882-016-0355-y

 received in 2015-10-28, accepted in 2016-09-21,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundTumoral calcinosis is a rare manifestation of extraskeletal calcification, featuring large calcified cystic masses in the periarticular regions of large joints. In chronic kidney disease (CKD), this disorder is thought to evolve through a chronically elevated calcium-phosphorus solubility product leading to calcium precipitation in soft tissue. Treating tumoral calcinosis in these patients involves interventions to lower the calcium-phosphorus product such as reduction in vitamin D therapy and intensive hemodialysis regimens.Case PresentationWe report the case of a 54-year old woman with polycystic kidney disease on peritoneal dialysis with widespread tumoral calcinosis in the context of hypercalcemic tertiary hyperparathyroidism who had been on long-term alfacalcidol therapy. After withdrawal of the vitamin D analogue and initiation of daily hemodialysis, there was rapid dissolution of her tumoral calcium deposits with the abrupt onset of parathyroid hormone (PTH)-independent transient hypercalcemia that resolved once the soft tissue deposits disappeared.ConclusionsResorption of soft tissue calcific deposits may result in transient parathyroid hormone (PTH)-independent hypercalcemia. In CKD patients, this hypercalcemia causes a decrease in the PTH level, distinguishing it from tertiary hyperparathyroidism, though PTH may not be totally suppressed, the way it is seen in PTH-independent hypercalcemia in non-CKD patients.

【 授权许可】

CC BY   
© The Author(s). 2016