Plasma fatty acids as diagnostic markers in autistic patients from Saudi Arabia

Lipids in Health and Disease

Research

Abir G Ben Bacha¹  Layla Y Al- Ayahdi²  Afaf K El-Ansary³ 

[1] Biochemistry Department, Science College, King Saud University, P.O Box 22452, Zip code 11495, Riyadh, Saudi Arabia;Autism Research and Treatment Center, King Saud University, P O Box 2925, 11461, Riyadh, Saudi Arabia;Shaik AL-Amodi Autism Research Chair, King Saud University, P O Box 2925, 11461, Riyadh, Saudi Arabia;Biochemistry Department, Science College, King Saud University, P.O Box 22452, Zip code 11495, Riyadh, Saudi Arabia;Autism Research and Treatment Center, King Saud University, P O Box 2925, 11461, Riyadh, Saudi Arabia;Shaik AL-Amodi Autism Research Chair, King Saud University, P O Box 2925, 11461, Riyadh, Saudi Arabia;Department of Physiology, Faculty of Medicine, King Saud University, P O Box 2925, 11461, Riyadh, Saudi Arabia;Biochemistry Department, Science College, King Saud University, P.O Box 22452, Zip code 11495, Riyadh, Saudi Arabia;Autism Research and Treatment Center, King Saud University, P O Box 2925, 11461, Riyadh, Saudi Arabia;Shaik AL-Amodi Autism Research Chair, King Saud University, P O Box 2925, 11461, Riyadh, Saudi Arabia;Medicinal Chemistry Department, National Research Centre, P O Box 12622, Dokki, Cairo, Egypt;

关键词: Autism;    Fatty acids;    Oxidative stress;    Valeric acid;    Propionic acid;    Polyunsaturated fatty acids;   

DOI  :  10.1186/1476-511X-10-62

 received in 2011-01-23, accepted in 2011-04-21,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundsAutism is a family of developmental disorders of unknown origin. The disorder is characterized by behavioral, developmental, neuropathological and sensory abnormalities, and is usually diagnosed between the ages of 2 and 10 with peak prevalence rates observed in children aged 5-8 years. Recently, there has been heightened interest in the role of plasma free fatty acids (FA) in the pathology of neurological disorders. The aim of this study is to compare plasma fatty acid profiles of Saudi autistic patients with those of age-matching control subjects in an attempt to clarify the role of FA in the etiology of autism.Methods26 autistic patients together with 26-age-matching controls were enrolled in the present study. Methyl esters of FA were extracted with hexane, and the fatty acid composition of the extract was analyzed on a gas chromatography.ResultsThe obtained data proved that fatty acids are altered in the plasma of autistic patients, specifically showing an increase in most of the saturated fatty acids except for propionic acid, and a decrease in most of polyunsaturated fatty acids. The altered fatty acid profile was discussed in relation to oxidative stress, mitochondrial dysfunction and the high lead (Pb) concentration previously reported in Saudi autistic patients. Statistical analysis of the obtained data shows that most of the measured fatty acids were significantly different in autistic patients compared to age -matching controls.ConclusionsReceiver Operating Characteristic (ROC) curve analysis shows satisfactory values of area under the curve (AUC) which could reflect the high degree of specificity and sensitivity of the altered fatty acids as biomarkers in autistic patients from Saudi Arabia.

【 授权许可】

CC BY   
© El-Ansary et al; licensee BioMed Central Ltd. 2011