Letrozole or clomiphene citrate as first line for anovulatory infertility: a debate

Reproductive Biology and Endocrinology

Debate

Mohan S Kamath¹  Korula George¹ 

[1] Reproductive Medicine Unit, Christian Medical College Hospital, 632004, Vellore, Tamil Nadu, India;

关键词: Aromatase Inhibitor;    Letrozole;    Clomiphene;    Line Therapy;    Ovulation Rate;   

DOI  :  10.1186/1477-7827-9-86

 received in 2010-12-21, accepted in 2011-06-21,  发布年份 2011

来源: Springer

【 摘 要 】

Clomiphene citrate has been traditionally used as the drug of choice in treating women with anovulatory infertility. In the last decade letrozole, an aromatase inhibitor has emerged as alternative ovulation induction agent. Literature confirms that letrozole has a definitive role in anovulatory women who have not responded to the clomiphene therapy. However its role as an alternative to clomiphene as first line therapy continues to be debated. Although it is probable that the overall benefits of letrozole surpass clomiphene citrate, currently available data does not confirm this view. There is need for large well-designed trials.

【 授权许可】

CC BY   
© Kamath and George; licensee BioMed Central Ltd. 2011