Association between preoperative serum sodium and postoperative 30-day mortality in adult patients with tumor craniotomy

BMC Neurology

Research

Yufei Liu¹  Zongyang Li²  Weiping Li²  Guodong Huang²  Yuandi Yang²  Fanfan Chen²  Liwei Zhang³  Haofei Hu⁴ 

[1] Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, Shenzhen Second People’s Hospital, the First Affiliated Hospital of Shenzhen University, No. 3002 Sungang west Road, Futian District, 518035, Shenzhen, Guangdong Province, China;Neurosurgical Department, Beijing Tiantan Hospital, Capital Medical University, No. 119, South Fourth Ring West Road, Fengtai District, 100070, Beijing, China;Shenzhen University Health Science Center, 518000, Shenzhen city, Guangdong Province, China;Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, Shenzhen Second People’s Hospital, the First Affiliated Hospital of Shenzhen University, No. 3002 Sungang west Road, Futian District, 518035, Shenzhen, Guangdong Province, China;Shenzhen University Health Science Center, 518000, Shenzhen city, Guangdong Province, China;Neurosurgical Department, Beijing Tiantan Hospital, Capital Medical University, No. 119, South Fourth Ring West Road, Fengtai District, 100070, Beijing, China;Shenzhen University Health Science Center, 518000, Shenzhen city, Guangdong Province, China;Nephrological Department, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, 518035, Shenzhen, Guangdong Province, China;

关键词: Sodium;    Brain tumor;    Craniotomy;    Nonlinear;    Mortality;   

DOI  :  10.1186/s12883-023-03412-2

 received in 2023-02-19, accepted in 2023-09-28,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundLimited data exist regarding preoperative serum sodium (Na) and 30-day mortality in adult patients with tumor craniotomy. Therefore, this study investigates their relationship.MethodsA secondary retrospective analysis was performed using data from the ACS NSQIP database (2012–2015). The principal exposure was preoperative Na. The outcome measure was 30-day postoperative mortality. Binary logistic regression modeling was conducted to explore the link between them, and a generalized additive model and smooth curve fitting were applied to evaluate the potential association and its explicit curve shape. We also conducted sensitivity analyses and subgroup analyses.ResultsA total of 17,844 patients (47.59% male) were included in our analysis. The mean preoperative Na was 138.63 ± 3.23 mmol/L. The 30-day mortality was 2.54% (455/17,844). After adjusting for covariates, we found that preoperative Na was negative associated with 30-day mortality. (OR = 0.967, 95% CI:0.941, 0.994). For patients with Na ≤ 140, each increase Na was related to a 7.1% decreased 30-day mortality (OR = 0.929, 95% CI:0.898, 0.961); for cases with Na > 140, each increased Na unit was related to a 8.8% increase 30-day mortality (OR = 1.088, 95% CI:1.019, 1.162). The sensitivity analysis and subgroup analysis indicated that the results were robust.ConclusionsThis study shows a positive and nonlinear association between preoperative Na and postoperative 30-day mortality in adult patients with tumor craniotomy. Appropriate preoperative Na management and maintenance of serum Na near the inflection point (140) may reduce 30-day mortality.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 1