Inotropic agents use in patients hospitalized with acute decompensated heart failure: a retrospective analysis from a 22-year registry in a Middle-Eastern Country (1991–2013)

BMC Cardiovascular Disorders

Research Article

Abdulrahman Arabi¹  Ashfaq Patel¹  Hajar A. AlBinali¹  Rajvir Singh²  Jassim Al Suwaidi³  Shaban F. K. Mohammed³  Amer H. S. Aljundi³ 

[1] Cardiology and Cardiovascular Surgery, Heart Hospital, Hamad Medical Corporation, Doha, Qatar;Cardiovascular Research, Heart Hospital, Hamad Medical Corporation, Doha, Qatar;Department of Clinical Pharmacology, Heart Hospital, Hamad Medical Corporation, P.O Box 3050, Doha, Qatar;

关键词: Inotropes;    Acute decompensated heart failure;    Predictors;    Length of stay;    Mortality;   

DOI  :  10.1186/s12872-016-0223-5

 received in 2015-01-09, accepted in 2016-02-11,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundData about the use of positive inotropic agents in patients hospitalized with acute decompensated heart failure (ADHF) is limited.MethodsThe records of 8066 patients with ADHF who were hospitalized at Hamad Medical Corporation, Qatar from 1991 to 2013 were analyzed to explore demographics and clinical characteristics of the patients according to inotropic agents use.ResultsEight hundred fifty eight patients [10.6 %, 95 % CI (10 to 11.3 %)] received intravenous inotropic support. Patients receiving inotropes were more likely to be female and have preserved ejection fraction when compared to those not receiving inotropic agents. Comorbidities associated with higher likelihood of receiving inotropic treatment included acute myocardial infarction, chronic renal impairment, dyslipidemia, hypertension, obesity and hyperglycemia. Patient on inotropes were more likely to undergone percutaneous coronary intervention (PCI), intra-aortic balloon pump support and intubation. There were no differences in the mean plasma BNP and CK-MB levels between the 2 groups. Heart failure patients receiving inotropes also were more likely to have complications including ventricular tachycardia (2.0 % vs. 0.9 %, p = 0.003), prolonged hospital stay (8.0 vs. 5.0 days, p = 0.001), cardiac arrest (14.6 % vs. 3.2 %, p = 0.001) and in-hospital mortality (30.8 % vs. 9.1 %, p = 0.001). Over the study period there was an increase use of inotropic agents and decreased mortality rates.ConclusionInotropic use increased over the period whereas; female gender and conventional cardiac risk factors were predictors of inotropic agents use in the study.

【 授权许可】

CC BY   
© Aljundi et al. 2016