Maternal nutrition modulates fetal development by inducing placental efficiency changes in gilts

BMC Genomics

Research Article

ZhenGuo Yang¹  Jian Li¹  Bin Feng¹  LianQiang Che¹  DaiWen Chen¹  Long Che¹  MengMeng Xu¹  ZhengFeng Fang¹  Yan Lin¹  De Wu¹  ShengYu Xu¹ 

[1] Key Laboratory of Animal Disease-Resistance Nutrition and Feed Science, Ministry of Agriculture, P. R. China, Institute of Animal Nutrition, Sichuan Agricultural University, 611130, Chengdu, China;

关键词: Energy level;    Gilts;    Fetal weight;    Placenta;    iTRAQ;   

DOI  :  10.1186/s12864-017-3601-1

 received in 2016-04-02, accepted in 2017-02-22,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundIntra-uterine growth restriction (IUGR) and fetal overgrowth increase risks to postnatal health. Maternal nutrition is the major intrauterine environmental factor that alters fetal weight. However, the mechanisms underlying the effects of maternal nutrition on fetal development are not entirely clear. We developed a pig model, and using isobaric tags for relative and absolute quantification (iTRAQ), we investigated alterations in the placental proteome of gilts on a normal-energy-intake (Con) and high-energy-intake (HE) diet.ResultsIn the Con group, heavy and light fetuses were found at the tubal and cervical ends of the uterus respectively at 90 d of gestation. Moreover, the heavy fetuses had a higher glucose concentration than the light fetuses. However, a higher uniformity was noted in the HE group. Placental promoters between these two positions indicated that 78 and 50 differentially expressed proteins were detected in the Con and HE groups respectively. In the Con group, these proteins were involved in lipid metabolism (HADHA, AACS, CAD), nutrient transport (GLUT, SLC27A1), and energy metabolism (NDUFV1, NDUFV2, ATP5C1). However, in the HE group they mainly participated in transcriptional and translational regulation, and intracellular vesicular transport.ConclusionsOur findings revealed that maternal nutrition may alter birth weight mainly through the modulation of placental lipid and energy metabolism, which also provides a possible mechanism to explain the higher uniformity of fetal weight in gilts fed a HE diet.

【 授权许可】

CC BY   
© The Author(s). 2017

【 图 表 】

Fig. 2