Cell adhesion and intracellular calcium signaling in neurons

Cell Communication and Signaling

Review

Vladimir Sytnyk¹  Lifu Sheng¹  Iryna Leshchyns’ka¹ 

[1] School of Biotechnology and Biomolecular Sciences, The University of New South Wales, 2052, Sydney, New South Wales, Australia;

关键词: Cell adhesion molecule;    Neurons;    Calcium;    Voltage dependent Ca channel;    Neurite outgrowth;   

DOI  :  10.1186/1478-811X-11-94

 received in 2013-10-22, accepted in 2013-12-05,  发布年份 2013

来源: Springer

【 摘 要 】

Cell adhesion molecules (CAMs) play indispensable roles in the developing and mature brain by regulating neuronal migration and differentiation, neurite outgrowth, axonal fasciculation, synapse formation and synaptic plasticity. CAM-mediated changes in neuronal behavior depend on a number of intracellular signaling cascades including changes in various second messengers, among which CAM-dependent changes in intracellular Ca2+ levels play a prominent role. Ca2+ is an essential secondary intracellular signaling molecule that regulates fundamental cellular functions in various cell types, including neurons. We present a systematic review of the studies reporting changes in intracellular Ca2+ levels in response to activation of the immunoglobulin superfamily CAMs, cadherins and integrins in neurons. We also analyze current experimental evidence on the Ca2+ sources and channels involved in intracellular Ca2+ increases mediated by CAMs of these families, and systematically review the role of the voltage-dependent Ca2+ channels (VDCCs) in neurite outgrowth induced by activation of these CAMs. Molecular mechanisms linking CAMs to VDCCs and intracellular Ca2+ stores in neurons are discussed.

【 授权许可】

Unknown   
© Sheng et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.