Metaproteomic analysis of human gut microbiota: where are we heading?

Journal of Biomedical Science

Review

Hui-min Neoh¹  Rahman Jamal¹  Pey Yee Lee¹  Siok-Fong Chin¹ 

[1] UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Cheras, 56000, Kuala Lumpur, Malaysia;

关键词: Metaproteomics;    Human;    Gut Microbiota;    Multi-omics;    Technologies;   

DOI  :  10.1186/s12929-017-0342-z

 received in 2017-03-15, accepted in 2017-06-01,  发布年份 2017

来源: Springer

【 摘 要 】

The human gut is home to complex microbial populations that change dynamically in response to various internal and external stimuli. The gut microbiota provides numerous functional benefits that are crucial for human health but in the setting of a disturbed equilibrium, the microbial community can cause deleterious outcomes such as diseases and cancers. Characterization of the functional activities of human gut microbiota is fundamental to understand their roles in human health and disease. Metaproteomics, which refers to the study of the entire protein collection of the microbial community in a given sample is an emerging area of research that provides informative details concerning functional aspects of the microbiota. In this mini review, we present a summary of the progress of metaproteomic analysis for studying the functional role of gut microbiota. This is followed by an overview of the experimental approaches focusing on fecal specimen for metaproteomics and is concluded by a discussion on the challenges and future directions of metaproteomic research.

【 授权许可】

CC BY   
© The Author(s). 2017