Association of vitamin D deficiency with hepatitis B virus - related liver diseases

BMC Infectious Diseases

Research Article

Nguyen Khuyen¹  Do Tuan Anh²  Phan Quoc Hoan³  Hoang Van Tong⁴  Mai Thanh Binh⁴  Peter G. Kremsner⁴  Christian G. Meyer⁴  Nghiem Xuan Hoan⁴  Dao Phuong Giang⁴  Thirumalaisamy P. Velavan⁵  Ngo Tat Trung⁶  Nguyen Linh Toan⁷  Le Huu Song⁸ 

[1]Department of Infectious Diseases, Duc Giang Hospital, Hanoi, Vietnam

[2]Department of Infectious Diseases, Vietnam Military Medical University, Hanoi, Vietnam

[3]Department of Molecular Biology, 108 Military Central Hospital, Hanoi, Vietnam

[4]Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany

[5]Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam

[6]Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany

[7]Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam

[8]Fondation Congolaise pour la Recherche Medicale, Brazzaville, Republic of Congo

[9]Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam

[10]Department of Molecular Biology, 108 Military Central Hospital, Hanoi, Vietnam

[11]Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam

[12]Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam

[13]Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam

[14]Institute of Clinical Infectious Diseases, 108 Military Central Hospital, Tran Hung Dao Street N1, Hai Ba Trung District, Hanoi, Vietnam

关键词: Vitamin D deficiency;    HBV infection;    Chronic liver disease;    Liver cirrhosis;    Hepatocellular carcinoma;   

DOI  :  10.1186/s12879-016-1836-0

 received in 2016-04-02, accepted in 2016-09-16,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundAs an immune modulator, vitamin D is involved in various pathophysiological mechanisms in a plethora of diseases. This study aims to correlate the vitamin D deficiency status and clinical progression of liver diseases associated with hepatitis B virus (HBV) infection in patients in Vietnam and to compare it to healthy controls.MethodsWe quantified the levels of total vitamin D [25-(OH) D2 and D3] in serum samples from 400 HBV patients (chronic hepatitis B infection [CHB], n = 165; HBV-associated liver cirrhosis [LC], n = 127; HBV-associated hepatocellular carcinoma [HCC], n = 108) and 122 unrelated healthy controls (HC). Univariate and multivariate analyses were performed in order to determine the association between vitamin D levels and distinct clinical parameters.ResultsThe prevalence of vitamin D inadequacy (<30 ng/mL) was high among healthy individuals (81.7 %) as well as in HBV patients (84.3 %). Vitamin D deficiency (<20 ng/ml) or severe deficiency (<10 ng/ml) was observed more frequently among HBV patients (52 %) and subgroups (CHB, 47.8 %; LC, 54.4 %; HCC, 55.3 %) compared to the control group (32.5 %) (P < 0.001). Vitamin D levels and HBV-DNA load were strongly and inversely correlated (rho = −0.57, P < 0.0001). Multivariate regression analysis also revealed an independent association of HBV-DNA loads with low vitamin D levels (P = 0.0004). In addition, reduced vitamin D levels were associated with significant clinical progression of LC (Child-Pugh C versus Child-Pugh A, P = 0.0018; Child-Pugh C versus Child-Pugh B, P = 0.016).ConclusionsVitamin D deficiency was observed in the majority of HBV-infected patients and associated with adverse clinical outcomes. Our findings suggest that substitution of vitamin D may be a supportive option in the treatment of chronic liver diseases, in particular of HBV-associated disorders.

【 授权许可】

CC BY   
© The Author(s). 2016