Journal of Nanobiotechnology | |
Radiotherapy combined with nano-biomaterials for cancer radio-immunotherapy | |
Review | |
Fang Liu1  Kun Zhang1  Tingyu Xue2  Haili Yan2  Ruixue Liu2  Qingrong Dong2  Hui Zhang2  Jiangfeng Du3  Yu Chong4  | |
[1] College of Pharmacy, Shanxi Medical University, 030619, Jinzhong, People’s Republic of China;Department of Medical Imaging, First Hospital of Shanxi Medical University, Intelligent Imaging Big Data and Functional Nano-Imaging Engineering Research Center of Shanxi Province, 030001, Taiyuan, People’s Republic of China;Department of Medical Imaging, First Hospital of Shanxi Medical University, Intelligent Imaging Big Data and Functional Nano-Imaging Engineering Research Center of Shanxi Province, 030001, Taiyuan, People’s Republic of China;College of Pharmacy, Shanxi Medical University, 030619, Jinzhong, People’s Republic of China;Collaborative Innovation Center for Molecular Imaging of Precision Medicine, Shanxi Medical University, 030001, Taiyuan, People’s Republic of China;State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, 215123, Suzhou, People’s Republic of China; | |
关键词: Radiotherapy; Immunotherapy; Nano-biomaterials; Radio-immunotherapy; Tumor; | |
DOI : 10.1186/s12951-023-02152-2 | |
received in 2023-06-06, accepted in 2023-10-09, 发布年份 2023 | |
来源: Springer | |
【 摘 要 】
Radiotherapy (RT) plays an important role in tumor therapy due to its noninvasiveness and wide adaptation. In recent years, radiation therapy has been discovered to induce an anti-tumor immune response, which arouses widespread concern among scientists and clinicians. In this review, we highlight recent advances in the applications of nano-biomaterials for radiotherapy-activated immunotherapy. We first discuss the combination of different radiosensitizing nano-biomaterials and immune checkpoint inhibitors to enhance tumor immune response and improve radiotherapy efficacy. Subsequently, various nano-biomaterials-enabled tumor oxygenation strategies are introduced to alleviate the hypoxic tumor environment and amplify the immunomodulatory effect. With the aid of nano-vaccines and adjuvants, radiotherapy refreshes the host's immune system. Additionally, ionizing radiation responsive nano-biomaterials raise innate immunity-mediated anti-tumor immunity. At last, we summarize the rapid development of immune modulatable nano-biomaterials and discuss the key challenge in the development of nano-biomaterials for tumor radio-immunotherapy. Understanding the nano-biomaterials-assisted radio-immunotherapy will maximize the benefits of clinical radiotherapy and immunotherapy and facilitate the development of new combinational therapy modality.Graphical Abstract
【 授权许可】
CC BY
© The Author(s) 2023
【 预 览 】
Files | Size | Format | View |
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RO202311104700487ZK.pdf | 2165KB | download | |
Fig. 3 | 603KB | Image | download |
Fig. 1 | 562KB | Image | download |
Fig. 2 | 2232KB | Image | download |
Fig. 3 | 2960KB | Image | download |
Fig. 4 | 1485KB | Image | download |
Fig. 5 | 2614KB | Image | download |
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