Radiotherapy combined with nano-biomaterials for cancer radio-immunotherapy

Journal of Nanobiotechnology

Review

Fang Liu¹  Kun Zhang¹  Tingyu Xue²  Haili Yan²  Ruixue Liu²  Qingrong Dong²  Hui Zhang²  Jiangfeng Du³  Yu Chong⁴ 

[1] College of Pharmacy, Shanxi Medical University, 030619, Jinzhong, People’s Republic of China;Department of Medical Imaging, First Hospital of Shanxi Medical University, Intelligent Imaging Big Data and Functional Nano-Imaging Engineering Research Center of Shanxi Province, 030001, Taiyuan, People’s Republic of China;Department of Medical Imaging, First Hospital of Shanxi Medical University, Intelligent Imaging Big Data and Functional Nano-Imaging Engineering Research Center of Shanxi Province, 030001, Taiyuan, People’s Republic of China;College of Pharmacy, Shanxi Medical University, 030619, Jinzhong, People’s Republic of China;Collaborative Innovation Center for Molecular Imaging of Precision Medicine, Shanxi Medical University, 030001, Taiyuan, People’s Republic of China;State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, 215123, Suzhou, People’s Republic of China;

关键词: Radiotherapy;    Immunotherapy;    Nano-biomaterials;    Radio-immunotherapy;    Tumor;   

DOI  :  10.1186/s12951-023-02152-2

 received in 2023-06-06, accepted in 2023-10-09,  发布年份 2023

来源: Springer

【 摘 要 】

Radiotherapy (RT) plays an important role in tumor therapy due to its noninvasiveness and wide adaptation. In recent years, radiation therapy has been discovered to induce an anti-tumor immune response, which arouses widespread concern among scientists and clinicians. In this review, we highlight recent advances in the applications of nano-biomaterials for radiotherapy-activated immunotherapy. We first discuss the combination of different radiosensitizing nano-biomaterials and immune checkpoint inhibitors to enhance tumor immune response and improve radiotherapy efficacy. Subsequently, various nano-biomaterials-enabled tumor oxygenation strategies are introduced to alleviate the hypoxic tumor environment and amplify the immunomodulatory effect. With the aid of nano-vaccines and adjuvants, radiotherapy refreshes the host's immune system. Additionally, ionizing radiation responsive nano-biomaterials raise innate immunity-mediated anti-tumor immunity. At last, we summarize the rapid development of immune modulatable nano-biomaterials and discuss the key challenge in the development of nano-biomaterials for tumor radio-immunotherapy. Understanding the nano-biomaterials-assisted radio-immunotherapy will maximize the benefits of clinical radiotherapy and immunotherapy and facilitate the development of new combinational therapy modality.Graphical Abstract

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 5

Fig. 4

Fig. 3

Fig. 2

Fig. 1

Fig. 3