期刊论文详细信息
Journal of Cardiovascular Magnetic Resonance
In-vivo T1 cardiovascular magnetic resonance study of diffuse myocardial fibrosis in hypertrophic cardiomyopathy
Research
Aernout M Beek1  Karin de Boer1  Tjeerd Germans1  Emma N Baars2  Wessel P Brouwer3  Albert C van Rossum3  Mark BM Hofman4  Jolanda van der Velden5 
[1] Department of Cardiology, ICaR-VU, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands;Department of Cardiology, ICaR-VU, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands;Department of Physics and Medical Technology, ICaR-VU, VU University Medical Center, Amsterdam, the Netherlands;Department of Cardiology, ICaR-VU, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands;Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands;Department of Physics and Medical Technology, ICaR-VU, VU University Medical Center, Amsterdam, the Netherlands;Department of Physiology, ICaR-VU, VU University Medical Center, Amsterdam, the Netherlands;
关键词: T1 mapping;    CMR;    Diffuse fibrosis;    HCM;    Extracellular volume fraction;   
DOI  :  10.1186/1532-429X-16-28
 received in 2012-01-31, accepted in 2014-03-17,  发布年份 2014
来源: Springer
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【 摘 要 】

BackgroundIn hypertrophic cardiomyopathy (HCM), autopsy studies revealed both increased focal and diffuse deposition of collagen fibers. Late gadolinium enhancement imaging (LGE) detects focal fibrosis, but is unable to depict interstitial fibrosis. We hypothesized that with T1 mapping, which is employed to determine the myocardial extracellular volume fraction (ECV), can detect diffuse interstitial fibrosis in HCM patients.MethodsT1 mapping with a modified Look-Locker Inversion Recovery (MOLLI) pulse sequence was used to calculate ECV in manifest HCM (n = 16) patients and in healthy controls (n = 14). ECV was determined in areas where focal fibrosis was excluded with LGE.ResultsThe total group of HCM patients showed no significant changes in mean ECV values with respect to controls (0.26 ± 0.03 vs 0.26 ± 0.02, p = 0.83). Besides, ECV in LGE positive HCM patients was comparable with LGE negative HCM patients (0.27 ± 0.03 vs 0.25 ± 0.03, p = 0.12).ConclusionsThis study showed that HCM patients have a similar ECV (e.g. interstitial fibrosis) in myocardium without LGE as healthy controls. Therefore, the additional clinical value of T1 mapping in HCM seems limited, but future larger studies are needed to establish the clinical and prognostic potential of this new technique within HCM.

【 授权许可】

CC BY   
© Brouwer et al.; licensee BioMed Central Ltd. 2014

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【 参考文献 】
  • [1]
  • [2]
  • [3]
  • [4]
  • [5]
  • [6]
  • [7]
  • [8]
  • [9]
  • [10]
  • [11]
  • [12]
  • [13]
  • [14]
  • [15]
  • [16]
  • [17]
  • [18]
  • [19]
  • [20]
  • [21]
  • [22]
  • [23]
  • [24]
  • [25]
  • [26]
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