Systemic vascular function, measured with forearm flow mediated dilatation, in acute and stable cerebrovascular disease: a case-control study

Cardiovascular Ultrasound

Research

Leonard Arnolda¹  Kathleen Potter²  Ian B Puddey³  Graeme J Hankey³  David Blacker⁴  Christopher D Beer⁵ 

[1] Cardiology, The Canberra Hospital, Canberra, Australia;Medical School, Australian National University, Canberra, Australia;School of Medicine and Pharmacology, University of Western Australia, Perth, Australia;School of Medicine and Pharmacology, University of Western Australia, Perth, Australia;Stroke Unit, Royal Perth Hospital, Perth, Australia;School of Medicine and Pharmacology, University of Western Australia, Perth, Australia;Stroke Unit, Sir Charles Gairdner Hospital, Perth, Australia;Western Australian Centre for Health and Ageing, University of Western Australia, Perth, Australia;School of Medicine and Pharmacology, University of Western Australia, Perth, Australia;Centre for Medical Research, Western Australian Institute for Medical Research, Perth, Australia;Stroke Unit, Royal Perth Hospital, Perth, Australia;

关键词: Ischaemic Stroke;    Acute Stroke;    Acute Ischaemic Stroke;    Vascular Function;    Flow Mediate Dilatation;   

DOI  :  10.1186/1476-7120-8-46

 received in 2010-08-26, accepted in 2010-10-19,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundAcute ischaemic stroke is associated with alteration in systemic markers of vascular function. We measured forearm vascular function (using forearm flow mediated dilatation) to clarify whether recent acute ischaemic stroke/TIA is associated with impaired systemic vascular function.MethodsProspective case control study enrolling 17 patients with recent acute ischaemic stroke/TIA and 17 sex matched controls with stroke more than two years previously. Forearm vascular function was measured using flow medicated dilatation (FMD).ResultsFlow mediated dilatation was 6.0 ± 1.1% in acute stroke/TIA patients and 4.7 ± 1.0% among control subjects (p = 0.18). The mean paired difference in FMD between subjects with recent acute stroke and controls was 1.25% (95% CI -0.65, 3.14; p = 0.18). Endothelium independent dilatation was measured in six pairs of participants and was similar in acute stroke/TIA patients (22.6 ± 4.3%) and control subjects (19.1 ± 2.6%; p = 0.43).ConclusionsDespite the small size of this study, these data indicate that recent acute stroke is not necessarily associated with a clinically important reduction in FMD.

【 授权许可】

CC BY   
© Beer et al; licensee BioMed Central Ltd. 2010