Comparison of inflammation, arterial stiffness and traditional cardiovascular risk factors between rheumatoid arthritis and inflammatory bowel disease

Journal of Inflammation

Research

David Andrew White¹  Xiao-lei Moore¹  Lu Fang¹  Abby Galvin²  Fenling Fan³  Anthony Michael Dart⁴  Miles Sparrow⁵  Flavia Cicuttini⁶ 

[1] Baker IDI Heart and Diabetes Institute, 75 Commercial Road, 3004, Melbourne, VIC, Australia;Department of Cardiovascular Medicine, The Alfred Hospital, Commercial Road, 3004, Melbourne, VIC, Australia;Baker IDI Heart and Diabetes Institute, 75 Commercial Road, 3004, Melbourne, VIC, Australia;Department of Cardiovascular Medicine, The Alfred Hospital, Commercial Road, 3004, Melbourne, VIC, Australia;Baker IDI Heart and Diabetes Institute, 75 Commercial Road, 3004, Melbourne, VIC, Australia;Department of Cardiovascular Medicine, The 1st Affiliated Hospital of Medical College, Xi’an Jiaotong University, 710061, Xi’an, China;Department of Cardiovascular Medicine, The Alfred Hospital, Commercial Road, 3004, Melbourne, VIC, Australia;Baker IDI Heart and Diabetes Institute, 75 Commercial Road, 3004, Melbourne, VIC, Australia;Department of Epidemiology and Preventative Medicine, Monash University, 3800, Melbourne, VIC, Australia;Department of Gastroenterology, The Alfred Hospital, Commercial Road, 3004, Melbourne, VIC, Australia;Department of Rheumatology, The Alfred Hospital, Commercial Road, 3004, Melbourne, VIC, Australia;Department of Epidemiology and Preventative Medicine, Monash University, 3800, Melbourne, VIC, Australia;

关键词: Inflammation;    Rheumatoid arthritis;    Inflammatory bowel disease;    Arterial stiffness;    Pulse wave velocity;   

DOI  :  10.1186/s12950-014-0029-0

 received in 2014-04-09, accepted in 2014-09-28,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundInflammation plays an important role in the pathogenesis of atherosclerosis. The link between rheumatoid arthritis (RA) and an increased risk of cardiovascular disease and mortality is well established; however, the association between inflammatory bowel disease (IBD) and cardiovascular risk is controversial. Arterial stiffness is both a marker and risk factor for atherosclerosis. Here we aimed to 1) compare circulating markers of inflammation and endothelial dysfunction, traditional cardiovascular risk factors, and arterial stiffness between RA and IBD to help to understand their different associations with cardiovascular disease; 2) assess the impacts of circulating markers of inflammation and endothelial dysfunction, and traditional risk factors on arterial stiffness.MethodsPatients with RA (n = 43) and IBD (n = 42), and control subjects (n = 73) were recruited. Plasma inflammatory markers and von Willebrand factor (vWF) were measured by Multiplex assays or ELISA. Arterial stiffness was determined by brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI) was measured. Framingham Risk Score (FRS) was calculated, and other traditional risk factors were also documented.ResultsPlasma levels of several inflammatory markers and vWF were significantly but comparably elevated in RA and IBD compared with controls, except for a higher level of C-reactive protein (CRP) in RA than IBD. Compared to controls, FRS, body mass index, waist circumference, and triglycerides were increased in RA, but not in IBD. baPWV did not significantly differ among 3 groups, while ABI was modestly but significantly lower in IBD than controls. Circulating markers (macrophage migration inhibitory factor, tumour necrosis factor-α, CRP, and vWF) were significantly associated with baPWV. However, traditional risk factors (age, systolic blood pressure, body mass index, diabetes and triglycerides) were the parameters associated with baPWV in multiple regression analyses (overall r = 0.866, p < 0.001).ConclusionsRA has a higher level of CRP and more pronounced traditional cardiovascular risk factors than IBD, which may contribute to the difference in their associations with cardiovascular disease and mortality. Traditional risk factors, rather than inflammation markers, are major predictors of arterial stiffness even in subjects with inflammatory disorders. Our results point to the importance of modifying traditional risk factors in patients with inflammatory disorders.

【 授权许可】

Unknown   
© Fan et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.