Ooplasmic transfer in human oocytes: efficacy and concerns in assisted reproduction

Reproductive Biology and Endocrinology

Review

Ashok Agarwal¹  Hamid Reza Khorram Khorshid²  Pallav Sengupta³  Mohammad Reza Sadeghi⁴  Mahsa Darbandi⁴  Mohammad Mehdi Akhondi⁴  Sara Darbandi⁴  Safaa Al-Hasani⁵ 

[1] Center for Reproductive Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA;Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran;Physiology Unit Faculty of Medicine Lincoln University College, Petaling Jaya, Malaysia;Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran;Reproductive Medicine Unit, University of Schleswig-Holstein, Luebeck, Germany;

关键词: Ooplasmic transfer;    Mitochondria;    Apoptosis;    Genetic modifications;    Epigenetic modifications;   

DOI  :  10.1186/s12958-017-0292-z

 received in 2017-05-23, accepted in 2017-09-06,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundOoplasmic transfer (OT) technique or cytoplasmic transfer is an emerging technique with relative success, having a significant status in assisted reproduction. This technique had effectively paved the way to about 30 healthy births worldwide. Though OT has long been invented, proper evaluation of the efficacy and risks associated with this critical technique has not been explored properly until today. This review thereby put emphasis upon the applications, efficacy and adverse effects of OT techniques in human.Main bodyAvailable reports published between January 1982 and August 2017 has been reviewed and the impact of OT on assisted reproduction was evaluated. The results consisted of an update on the efficacy and concerns of OT, the debate on mitochondrial heteroplasmy, apoptosis, and risk of genetic and epigenetic alteration.Short conclusionThe application of OT technique in humans demands more clarity and further development of this technique may successfully prove its utility as an effective treatment for oocyte incompetence.

【 授权许可】

CC BY   
© The Author(s). 2017