Evolution and bad prognostic value of advanced glycation end products after acute heart failure: relation with body composition

Cardiovascular Diabetology

Original Investigation

Marcos C. Carreira¹  Ana I. Castro-Pais²  Felipe F. Casanueva²  Ángel Fernández-Trasancos³  Diana Bou-Teen³  Beatriz Paradela-Dobarro⁴  Ezequiel Álvarez⁴  Sonia Eiras⁴  José R. González-Juanatey⁵  Rosa M. Agra⁵  Alfonso Varela-Román⁵  Rocío González-Ferreiro⁶ 

[1] CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Madrid, Spain;División de Endocrinología, Departamento de Medicina, Complejo Hospitalario Universitario de Santiago (CHUS) and Universidad de Santiago de Compostela (USC), Santiago de Compostela, Spain;CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Madrid, Spain;Laboratorio no. 6. Edif. Consultas externas (planta -2), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Travesía da Choupana s/n, Santiago de Compostela, 15706, A Coruña, Spain;Laboratorio no. 6. Edif. Consultas externas (planta -2), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Travesía da Choupana s/n, Santiago de Compostela, 15706, A Coruña, Spain;CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain;Laboratorio no. 6. Edif. Consultas externas (planta -2), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Travesía da Choupana s/n, Santiago de Compostela, 15706, A Coruña, Spain;CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain;Servicio de Cardiología y Unidad de Hemodinámica, Complejo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Universidad de Santiago de Compostela, Santiago de Compostela, 15706, A Coruña, Spain;Servicio de Cardiología y Unidad de Hemodinámica, Complejo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Universidad de Santiago de Compostela, Santiago de Compostela, 15706, A Coruña, Spain;

关键词: Acute heart failure;    Advanced glycation end products;    Soluble RAGE;    Heart failure progression;    Heart failure prognosis;   

DOI  :  10.1186/s12933-017-0598-3

 received in 2017-06-30, accepted in 2017-09-07,  发布年份 2017

来源: Springer

【 摘 要 】

AimThe role of advanced glycation end products (AGEs) and their soluble receptor (sRAGE) on the progression and prognosis of acute heart failure (HF) was analysed in relation with metabolic parameters as body composition and nutritional status.MethodsA hundred and fifty consecutive patients were included in a prospective clinical study during hospitalization by acute HF. Detailed medical history, physical examination, electrocardiogram, echocardiogram and vein peripheral blood were taken for all patients. During the follow-up period [297 days (88–422 days)] blood samples for biochemical measurements were obtained 1 and 6 months after the inclusion. Dual-energy X-ray absorptiometry analyses were performed 1 week after discharge.ResultsAGEs and sRAGE levels continuously increased, up to 6 months, after acute HF, but AGEs increase was mainly observed in those patients with incident HF. Both AGEs and sRAGE levels were related with bad renal function and clinical malnutrition (CONUT score) and they were negatively related with body mass index or percentage of body fat. AGEs levels (≥40 a.u.) 1 month after discharge and basal sRAGE levels (>1000 pg/mL) were related with worse prognosis in terms of patient death and HF readmission (Log-rank <0.05 in Kaplan–Meier survival test), independently of age, gender, body mass index and other risk factors. Regression models also corroborated this finding.ConclusionsAGEs and sRAGE are bad prognostic biomarkers for HF and useful markers of HF progression. Since their levels seem to be related with clinical malnutrition and body composition these parameters could serve to modulate them.

【 授权许可】

CC BY   
© The Author(s) 2017