MicroRNA-9 expression is a prognostic biomarker in patients with osteosarcoma

World Journal of Surgical Oncology

Research

Shu-mei Han¹  Shi-hong Xu²  Yong-liang Yang²  Zong-hui Wu³ 

[1] Department of Medicine, Shandong Cancer Hospital and Institute, 250117, Jinan, Shandong, China;Department of Orthopedics, Shandong Provincial Hospital affiliated to Shandong University, 250021, Jinan, Shandong, China;Department of ultrasound diagnosis, Shandong Medical Imaging Research Institute, Shandong University, 324 Jingwu Road, 250021, Jinan, Shandong Province, China;

关键词: Osteosarcoma;    MicroRNA-9;    Prognosis;   

DOI  :  10.1186/1477-7819-12-195

 received in 2014-03-07, accepted in 2014-06-12,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe purpose of the present study was to examine the expression levels of microRNA-9 (miR-9) in osteosarcoma tissues and normal bone tissues, and investigate the relationships between miR-9 expression, clinicopathological features and the prognosis of patients with osteosarcoma.MethodsThe expression levels of miR-9 in osteosarcoma tissues and corresponding non-cancerous tissues were detected using a real-time quantitative assay. Differences in patient survival were determined using the Kaplan–Meier method and a log-rank test. A Cox proportional hazards regression analysis was used for univariate and multivariate analyses of prognostic values.ResultsCompared to non-cancerous bone tissues, the expression levels of miR-9 in osteosarcoma tissues were significantly elevated (P < 0.001). We found that the expression level of miR-9 was significantly associated with tumor size (P = 0.011), clinical stage (P = 0.009) and distant metastasis (P < 0.001). The Kaplan–Meier curve showed that patients with low miR-9 expression survived significantly longer than patients with high miR-9 expression (P = 0.0017). Multivariate analysis suggested that miR-9 expression level (P = 0.002) is an independent prognostic factors for overall survival.ConclusionsThe findings of our study suggest that increased miR-9 expression has a strong correlation with the aggressive progression of osteosarcoma and its overexpression is a statistically significant risk factor affecting overall survival, suggesting that increased miR-9 expression could be a valuable marker of tumor progression and for prognosis of osteosarcoma.

【 授权许可】

Unknown   
© Xu et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.