Prevalence of hepatitis B and delta according to HIV-type: a multi-country cross-sectional survey in West Africa

BMC Infectious Diseases

Research Article

Daouda K. Minta¹  Gilles Wandeler²  Geoffrey S. Gottlieb³  Patrick A. Coffie⁴  Serge P. Eholie⁴  Mathieu Kabran⁵  Guillaume Bado⁶  François Dabis⁷  Boris K. Tchounga⁸  Didier K. Ekouevi⁹ 

[1] Centre de Prise en Charge des Personnes vivant avec le VIH, Service de Maladies Infectieuses, Hôpital du Point G, Bamako, Mali;Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland;Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland;Departments of Medicine & Global Health, University of Washington, Seattle, USA;Département de Dermatologie et d’Infectiologie, UFR des Sciences Médicales, Université Félix Houphouët Boigny, BP V3 Abidjan, CHU de Treichville, Abidjan, Côte d’Ivoire;Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Treichville, Abidjan, Côte d’Ivoire;Programme PACCI, site de recherche ANRS, Abidjan, Côte d’Ivoire;Département d’Hématologie, d’immunologie et de biologie cellulaire, UFR des Sciences Pharmaceutiques, Université Félix Houphouët Boigny, Abidjan, Côte d’Ivoire;Hôpital de Jour, Service des Maladies Infectieuses et Tropicales, CHU Souro Sanou, Bobo Dioulasso, Burkina Faso;ISPED, Université de Bordeaux & Centre INSERM U1219 - Bordeaux Population Health, Bordeaux, France;Programme PACCI, site de recherche ANRS, Abidjan, Côte d’Ivoire;ISPED, Université de Bordeaux & Centre INSERM U1219 - Bordeaux Population Health, Bordeaux, France;Programme PACCI, site de recherche ANRS, Abidjan, Côte d’Ivoire;ISPED, Université de Bordeaux & Centre INSERM U1219 - Bordeaux Population Health, Bordeaux, France;Université de Lomé, Département des Sciences Fondamentales et Santé Publique, Lomé, Togo;

关键词: HIV-2;    HBV;    HBV and HDV coinfection;    West Africa;   

DOI  :  10.1186/s12879-017-2568-5

 received in 2017-02-22, accepted in 2017-06-26,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundIn West Africa where HIV-1 and HIV-2 co-circulate, the co-infection with hepatitis B virus (HBV) and hepatitis Delta virus (HDV) is not well described. This study aimed at estimating the prevalence of HBV and HBV/HDV co-infection according to HIV types and risk factors for HBV infection among West African HIV-infected patients.MethodA cross-sectional survey was conducted within the IeDEA West Africa cohort from March to December 2012 in Côte d’Ivoire (three sites), Burkina Faso and Mali (one site each). All HIV-infected adult patients on antiretroviral therapy (ART) or not who attended one of the participating HIV clinics during the study period and agreed to participate were included. Blood samples were collected and re-tested for HIV type discrimination, HBV and HDV serology as well as HBV viral load. Logistic regression was used to identify risk factors for HBV infection.ResultsA total of 791 patients were included: 192 HIV-1, 447 HIV-2 and 152 HIV-1&2 dually reactive. At time of sampling, 555 (70.2%) were on ART and median CD4+ cell count was 472/mm3 (inter-quartile range [IQR]: IQR: 294–644). Sixty-seven (8.5%, 95% CI 6.6–10.6) patients were HBsAg positive without any difference according to HIV type (7.9% in HIV-1, 7.2% in HIV-1&2 dually reactive and 9.4% in HIV-2; p = 0.61). In multivariate logistic analysis, age ≤ 30 years old (adjusted odds ratio [aOR] 5.00, 95% CI 1.96–12.76), age between 31 and 49 years old (aOR 1.78, 95% CI 1.00–2.21) and male gender (aOR 2.15, 95% CI 1.25–3.69) were associated with HBsAg positivity. HBV DNA testing was performed in 36 patients with blood sample available (25 on ART) and 8 (22.2%) had detectable HBV DNA. Among the HBsAg-positive individuals, 14.9% (95% CI 7.4–25.7) were also positive for anti-HDV antibody without any difference according to HIV type (28.6% in HIV-1, 14.3% in HIV-2 and 0.0% in HIV-1&2 dually reactive; p = 0.15).ConclusionHBV and HBV/HDV co-infection are common in West Africa, irrespective of HIV type. Therefore, screening for both viruses should be systematically performed to allow a better management of HIV-infected patients. Follow-up studies are necessary to determine the impact of these two viruses on HIV infection.

【 授权许可】

CC BY   
© The Author(s). 2017