期刊论文

【摘要】

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting 5–10 % of women of reproductive age. It generally manifests with oligo/anovulatory cycles, hirsutism and polycystic ovaries, together with a considerable prevalence of insulin resistance. Although the aetiology of the syndrome is not completely understood yet, PCOS is considered a multifactorial disorder with various genetic, endocrine and environmental abnormalities. Moreover, PCOS patients have a higher risk of metabolic and cardiovascular diseases and their related morbidity, if compared to the general population.

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© The Author(s). 2016

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Reproductive Biology and Endocrinology
Genetic, hormonal and metabolic aspects of PCOS: an update
Review
G. Morgante¹ V. De Leo¹ V. Cappelli¹ F. Petraglia¹ M. G. Massaro¹ M. C. Musacchio¹
[1] Department Molecular Medicine and Development, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100, Siena, Italy;
关键词: PCOS; Genetic; Insulin-resistance; Hyperandrogenism; Infertility; Metformin; Oral contraceptives; Myo-inositol;
DOI : 10.1186/s12958-016-0173-x
received in 2016-05-03, accepted in 2016-07-08, 发布年份 2016
来源: Springer
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