Intravenous theophylline is the most effective intervention to prolong EEG seizure duration in patients undergoing electroconvulsive therapy

BMC Anesthesiology

Research Article

Alexander Tzabazis¹  Hubert J. Schmitt²  Michaela E. Wiernik²  Tino Münster²  Harald Ihmsen²  Jan Wielopolski³  Wolfgang Sperling⁴ 

[1] Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, School of Medicine, 300 Pasteur Dr, 94305, Stanford, CA, USA;Department of Anesthesiology, University Hospital of Erlangen, Krankenhausstrasse 12, 91054, Erlangen, Germany;Department of Psychiatry and Psychotherapy, University Hospital Zürich, Culmannstrasse 8, 8091, Zürich, Switzerland;Department of Psychiatry, University Hospital of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany;

关键词: ECT;    Seizure duration;    Theophylline;    Remifentanil;    (S-)ketamine;    Barbiturate;    Thiopental;    Etomidate;    Abbreviations.;    ECT Electroconvulsive therapy;    EEG Electroencephalogram.;    US United States.;   

DOI  :  10.1186/s12871-017-0412-5

 received in 2017-02-08, accepted in 2017-08-25,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundSeizure duration in electroconvulsive therapy (ECT) is positively related with patients’ outcome. This study sought to investigate the impact of anesthetic management on seizure duration, and the impact of selected drugs (theophylline, remifentanil, S-ketamine) on seizure duration.MethodsRetrospective analysis of all patients undergoing ECT at our institution from January 2011 to April 2012 was performed based on electronic medical chart and review of existing quality improvement data. Patient data (N = 78), including gender, age, height, weight, and administered drugs, energy levels, and electroencephalic seizure duration were analyzed. Statistical analysis was performed using a generalized linear model.ResultsA total of 78 patients (male = 39, female = 39, age 51 ± 12 years) were included. Average number of session was 10 ± 6 (1–30). In our patient population, theophylline administration was the only parameter, which significantly prolonged seizure duration, whereas S-ketamine, remifentanil, thiopental, age, sex, session or energy level had no significant effect.ConclusionTheophylline can be a useful adjunct for patients with inadequate seizure duration. If there is a concomitant beneficial effect on patients’ outcome needs to be investigated in further studies.

【 授权许可】

CC BY   
© The Author(s). 2017