Non-tuberculous mycobacteria (NTM) in Zambia: prevalence, clinical, radiological and microbiological characteristics

BMC Infectious Diseases

Research Article

Martin P. Grobusch¹  Nathan Kapata²  Lutinala Mulenga³  Peter Mwaba⁴  Pascalina Chanda-Kapata⁵  Eveline Klinkenberg⁶  Veronica Sunkutu⁷  Mathias Tembo⁸  Patrick Katemangwe⁹ 

[1] Center of Tropical Medicine and Travel Medicine, Amsterdam Medical Centre, University of Amsterdam, Amsterdam, Netherlands;Center of Tropical Medicine and Travel Medicine, Amsterdam Medical Centre, University of Amsterdam, Amsterdam, Netherlands;Department of Epidemics and Disease Control, Ministry of Community Development, Mother and Child Health, 10101, Lusaka, Zambia;Department of Clinical Care and Diagnostics, Chest Diseases Laboratory, Ministry of Health, 10101, Lusaka, Zambia;Department of Disease Surveillance, Control and Research, Ministry of Health, Lusaka, Zambia;Department of Disease Surveillance, Control and Research, Ministry of Health, Lusaka, Zambia;Center of Tropical Medicine and Travel Medicine, Amsterdam Medical Centre, University of Amsterdam, Amsterdam, Netherlands;KNCV Tuberculosis Foundation, The Hague, Netherlands;Department of Global Health and Development, Amsterdam Medical Centre, Amsterdam, Netherlands;Radiology Department, University Teaching Hospital, 10101, Lusaka, Zambia;Tuberculosis Laboratory, Tropical Diseases Research Centre, Ndola, Zambia;Tuberculosis Laboratory, University Teaching Hospital, 10101, Lusaka, Zambia;

关键词: Epidemiology;    Survey;    Non-tuberculous mycobacteria;    Emerging;    Public health;    Diagnosis;   

DOI  :  10.1186/s12879-015-1264-6

 received in 2015-04-01, accepted in 2015-11-05,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundNon-tuberculous mycobacteria (NTM) infection is an emerging health problem. We present here the Zambia-specific national level data of prevalence, symptomatic, radiological and microbiological characteristics of NTM, using results from a national Tuberculosis (TB) prevalence survey.MethodsThis was a cross-sectional study of the prevalence of NTM among adults aged 15 years and above, who were participants in a national TB prevalence survey. Participants who had either an abnormal chest x-ray or were symptomatic were considered presumptive TB cases and submitted sputum for smear and culture analysis. HIV testing was performed on an opt-out basis. Symptomatic NTM prevalence was estimated from individual level analysis.ResultsOf the 6,123 individuals with presumptive TB, 923 (15.1 %) were found to have NTM, 13 (0.2 %) were MTB/NTM co-infected and 338 (5.5 %) were contaminated (indeterminate). The prevalence of symptomatic NTM was found to be 1,477/100,000 [95 % CI 1010–1943]. Smear positivity, history of cough or chest pain and HIV positivity were risk factors for NTM.ConclusionThis first study to estimate the national prevalence of NTM in Zambia indicates that the burden is high. The NTM occurrence in Zambia constitutes both a public health and ethical issue requiring action from health managers.

【 授权许可】

CC BY   
© Chanda-Kapata et al. 2015