Artemisone effective against murine cerebral malaria

Malaria Journal

Research

Wing-Chi Chan¹  Richard K Haynes¹  Ho-Wai Chan¹  Annael Bentura-Marciano²  Jacob Golenser³  Judith H Waknine-Grinberg⁴  James A McQuillan⁵  Nicholas Hunt⁵  Yechezkel Barenholz⁶ 

[1] Department of Chemistry, Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong;Department of Microbiology and Molecular Genetics, The Hebrew University of Jerusalem, 91120, Jerusalem, Israel;Department of Microbiology and Molecular Genetics, The Hebrew University of Jerusalem, 91120, Jerusalem, Israel;Department of Pathology and Bosch Institute, The University of Sydney, Sydney, Australia;Department of Microbiology and Molecular Genetics, The Hebrew University of Jerusalem, 91120, Jerusalem, Israel;Laboratory of Membrane and Liposome Research, Department of Biochemistry, Institute for Medical Research - Israel-Canada, The Hebrew University of Jerusalem - Hadassah Medical School, Jerusalem, Israel;Department of Pathology and Bosch Institute, The University of Sydney, Sydney, Australia;Laboratory of Membrane and Liposome Research, Department of Biochemistry, Institute for Medical Research - Israel-Canada, The Hebrew University of Jerusalem - Hadassah Medical School, Jerusalem, Israel;

关键词: Malaria;    Chloroquine;    Cerebral Malaria;    Artesunate;    Artemether;   

DOI  :  10.1186/1475-2875-9-227

 received in 2010-05-05, accepted in 2010-08-09,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundArtemisinins are the newest class of drug approved for malaria treatment. Due to their unique mechanism of action, rapid effect on Plasmodium, and high efficacy in vivo, artemisinins have become essential components of malaria treatment. Administration of artemisinin derivatives in combination with other anti-plasmodials has become the first-line treatment for uncomplicated falciparum malaria. However, their efficiency in cases of cerebral malaria (CM) remains to be determined.MethodsThe efficacy of several artemisinin derivatives for treatment of experimental CM was evaluated in ICR or C57BL/6 mice infected by Plasmodium berghei ANKA. Both mouse strains serve as murine models for CM.ResultsArtemisone was the most efficient drug tested, and could prevent death even when administered at relatively late stages of cerebral pathogenesis. No parasite resistance to artemisone was detected in recrudescence. Co-administration of artemisone together with chloroquine was more effective than monotherapy with either drug, and led to complete cure. Artemiside was even more effective than artemisone, but this substance has yet to be submitted to preclinical toxicological evaluation.ConclusionsAltogether, the results support the use of artemisone for combined therapy of CM.

【 授权许可】

Unknown   
© Waknine-Grinberg et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.