Pet cats may shape the antibiotic resistome of their owner’s gut and living environment

Microbiome

Research

Nan Hu¹  Yilin Yuan²  Xindi Liao²  Yinbao Wu²  Yiwen Yang²  Yan Wang²  Xinwen Hu³  Shuang Cai⁴  Jiandui Mi⁵ 

[1] Department of Rehabilitation, The Second Affiliated Hospital of Guangzhou Medical University, 510260, Guangzhou, China;Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, Guangdong Laboratory of Lingnan Modern Agriculture, College of Animal Science, South China Agriculture University, 510642, Guangzhou, China;Institute of Digestive Disease, Faculty of Medicine, Chinese University of Hong Kong, 999077, Hong Kong, China;State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, 100193, Beijing, China;State Key Laboratory of Veterinary Etiological Biology, College of Veterinary Medicine, Lanzhou University, 730000, Lanzhou, China;

关键词: Antibiotic resistome;    Pet cat;    Human;    Gut;    Living environment;   

DOI  :  10.1186/s40168-023-01679-8

 received in 2023-03-15, accepted in 2023-09-27,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundCompanion animals can contribute to the physical and mental health of people and often live in very close association with their owners. However, the antibiotic resistome carried by companion animals and the impact they have on their owners and living environment remain unclear. In this study, we compared the ARG profiles of cats, humans, and their living environments using metagenomic analysis to identify the core ARGs in the cat and human gut and explore the potential impact of cats on ARGs in the human gut through the environment.ResultsResults showed that the abundance of ARGs in the cat gut was significantly higher than that in the human gut (P < 0.0001), with aminoglycoside and tetracycline resistance genes being the dominant ARGs in the cat gut. There was no significant difference in the abundance of total ARGs in the guts of cat owners and non-owners (P > 0.05). However, the abundance of aminoglycoside resistance genes including APH(2'')-IIa and AAC(6')-Im was significantly higher in cat owners than that in non-cat owners (P < 0.001). Also, ARG abundance was positively correlated with the frequency of cat activity in the living environment. Enterobacteriaceae was the dominant ARG host co-occurring in the cat gut, human gut, and living environment.ConclusionsOur results show that cats may shape the living environment resistome and thus the composition of some ARGs in the human gut, highlighting the importance of companion animal environment health.CA_8GzYC3SY3RzvHMSVpYQVideo Abstract

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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