Prognostic value of pretreatment standardized uptake value of F-18-fluorodeoxyglucose PET in patients with gastric cancer: a meta-analysis

BMC Cancer

Research Article

Yongxi Song¹  Zhenning Wang¹  Xiaowan Chen¹  Zhonghua Wu¹  Bin Ma¹  Junhua Zhao¹  Peng Gao¹  Jingxu Sun¹ 

[1] Department of Surgical Oncology and General Surgery, The First Affiliated Hospital of China Medical University, 155 North Nanjing Street, Heping District, 110001, Shenyang, People’s Republic of China;

关键词: Gastric cancer;    Positron emission tomography;    Standardized uptake value;    Prognosis;    Meta-analysis;   

DOI  :  10.1186/s12885-017-3271-z

 received in 2016-08-18, accepted in 2017-04-07,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundF-18- fluorodeoxyglucose Positron emission tomography (18FDG-PET) has been widely used in clinical practice. However, the prognostic value of the pretreatment standardized uptake value (SUV) for patients with gastric cancer remains controversial.MethodsMajor databases were systematically searched. The quality of the included studies was assessed using the Newcastle–Ottawa scale; the PET protocols were also evaluated. The pooled hazard ratio (HR) for overall survival (OS) and recurrence-free survival (RFS) were used to estimate the effect size. Data from the included studies were analyzed using Review Manager Software version 5.2.ResultsEight studies with 1080 patients were included. The pooled HR for OS of six studies including 672 patients was 1.72 (95% CI [1.28–2.3], p = 0.0004, I2 = 0%), indicating that patients with high SUVs may have poor prognosis. The pooled HR for RFS was 1.70 (95% CI [1.20–2.39], p = 0.003, I2 = 0%). Subgroup analysis based on the cutoff values determining method indicated that the receiver operating characteristic (ROC) method could better define the cutoff value. Subgroup analysis based on the therapeutic strategies used subsequently indicated the significant prognostic value of SUV.ConclusionIn conclusion, our meta-analysis indicated that pretreatment SUV in primary lesions can be an important prognostic factor for overall survival and recurrence-free survival in patients with gastric cancer. High SUVs may indicate poor prognosis.

【 授权许可】

CC BY   
© The Author(s). 2017